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Artigo Acesso aberto Revisado por pares
BIBTEX RIS

Mechanisms underlying genetic susceptibility to multisystem inflammatory syndrome in children (MIS-C)

2021; Elsevier BV; Volume: 148; Issue: 3 Linguagem: Inglês

10.1016/j.jaci.2021.06.024

ISSN

1097-6825

Autores

Janet Chou, Craig D. Platt, Saddiq B. Habiballah, Alan A. Nguyen, Megan Elkins, Sabrina Weeks, Zachary Peters, Megan Day‐Lewis, Tanya Novak, Myriam Armant, Lucinda Williams, Shira Rockowitz, Piotr Sliz, David A. Williams, Adrienne G. Randolph, Raif S. Geha, Abduarahman Almutairi, Faris Jaber, Tina Banzon, Jordan E. Roberts, Olha Halyabar, Mindy S. Lo, Stacy A. Kahn, Lauren A. Henderson, Pui Y. Lee, Mary Beth F. Son, Leah Cheng,

Tópico(s)

interferon and immune responses

Resumo

Multisystem inflammatory syndrome in children (MIS-C) is a pediatric complication of severe acute respiratory syndrome coronavirus 2 infection that is characterized by multiorgan inflammation and frequently by cardiovascular dysfunction. It occurs predominantly in otherwise healthy children. We previously reported haploinsufficiency of suppressor of cytokine signaling 1 (SOCS1), a negative regulator of type I and II interferons, as a genetic risk factor for MIS-C.

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