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Incidence, Clinical Characteristics and Management of Inflammatory Bowel Disease in Spain: Large-Scale Epidemiological Study

2021; Multidisciplinary Digital Publishing Institute; Volume: 10; Issue: 13 Linguagem: Inglês

10.3390/jcm10132885

2077-0383

María Chaparro, Ana Garre, Andrea Núñez Ortiz, M T Diz-Lois Palomares, Cristina Rodríguez, Sabino Riestra, Milagros Vela, J M Benítez, Estela Fernández Salgado, Eugenia Sánchez Rodríguez, Vicent Hernández, R Ferreiro-Iglesias, Ángel Ponferrada Díaz, Jesús Barrio, José María Huguet, Beatriz Sicilia, María Dolores Martín‐Arranz, Xavier Calvet, Daniel Ginard, Inmaculada Alonso-Abreu, Luís Fernández-Salazar, Pilar Varela Trastoy, Montserrat Rivero, Isabel Vera-Mendoza, Pablo Vega, Pablo Navarro, Mónica Sierra, José Luis Cabriada, Mariam Aguas, Raquel Vicente, Mercè Navarro-Llavat, Ana Echarri, Fernando Gomollón, Elena Guerra del Río, Concepción Piñero, María José Casanova, Kateřina Špičáková, Jone Ortiz de Zárate, Emilio Torrella Cortés, Ana Gutiérrez, Horacio Alonso‐Galán, Álvaro Hernández-Martínez, José Miguel Marrero, Rufo Lorente Poyatos, Margalida Calafat, Lidia Martí Romero, Pilar Robledo, Orencio Bosch, Nuria Jiménez, María Esteve, José María Duque, Ana Fuentes Coronel, Manuela Josefa Sampedro, Eva Sesé Abizanda, Belén Herreros Martínez, Liliana Pozzati, Hipólito Fernández Rosáenz, Belén Crespo Suarez, Pilar López Serrano, Alfredo J. Lucendo, Margarita Muñoz Vicente, Fernando Bermejo, José Ramírez Palanca, Margarita Menacho, Amalia Carmona, Raquel Camargo, Sandra Torrá Alsina, Nuria Maroto, Juan Nerín de la Puerta, Elena Castro, Ignacio Marín‐Jiménez, Belén Botella, Amparo Sapiña, Noelia Cruz, José Luis Fernández Forcelledo, Abdel Bouhmidi, Carlos Castańo-Milla, Verónica Opio, Isabel Nicolás, Marcos Kutz, A. Abraldes Bechiarelli, Jordi Gordillo, Yolanda Ber, Yolanda Torres Domínguez, M. Novella Durán, Silvia Rodríguez Mondéjar, Francisco J. Martínez-Cerezo, Lilyan Kolle, M Sàbat, César Ledezma, Eduardo Iyo, Óscar Roncero, Rebeca Irisarri, Laia Lluis, Isabel Blázquez Gómez, Eva Zapata, María José Fernández Alcalá, Cristina Martínez Pascual, María Montealegre, Laura Mata, Ana Monrobel, Alejandro Hernández-Camba, Luis Hernández, Marı́a Jesús Gómez de Tejada, Alberto Mir, María Luisa Galve, Marta Soler, Daniel Hervías, José Antonio Gómez-Valero, Manuel Barreiro‐de Acosta, Fernando Rodríguez‐Artalejo, Esther García‐Esquinas, Javier P. Gisbert,

Pregnancy and Medication Impact

(1) Aims: To assess the incidence of inflammatory bowel disease (IBD) in Spain, to describe the main epidemiological and clinical characteristics at diagnosis and the evolution of the disease, and to explore the use of drug treatments. (2) Methods: Prospective, population-based nationwide registry. Adult patients diagnosed with IBD-Crohn's disease (CD), ulcerative colitis (UC) or IBD unclassified (IBD-U)-during 2017 in Spain were included and were followed-up for 1 year. (3) Results: We identified 3611 incident cases of IBD diagnosed during 2017 in 108 hospitals covering over 22 million inhabitants. The overall incidence (cases/100,000 person-years) was 16 for IBD, 7.5 for CD, 8 for UC, and 0.5 for IBD-U; 53% of patients were male and median age was 43 years (interquartile range = 31-56 years). During a median 12-month follow-up, 34% of patients were treated with systemic steroids, 25% with immunomodulators, 15% with biologics and 5.6% underwent surgery. The percentage of patients under these treatments was significantly higher in CD than UC and IBD-U. Use of systemic steroids and biologics was significantly higher in hospitals with high resources. In total, 28% of patients were hospitalized (35% CD and 22% UC patients, p < 0.01). (4) Conclusion: The incidence of IBD in Spain is rather high and similar to that reported in Northern Europe. IBD patients require substantial therapeutic resources, which are greater in CD and in hospitals with high resources, and much higher than previously reported. One third of patients are hospitalized in the first year after diagnosis and a relevant proportion undergo surgery.