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Alterations in Metabolic Relations and Adiposity during and after Cigarette Smoke Exposition, in Young Female and Male Mice

2015; Wiley; Volume: 29; Issue: S1 Linguagem: Inglês

10.1096/fasebj.29.1_supplement.995.3

1530-6860

Rejane P Gaspar-Reis, Cynthia S Silva, Aline Silva Santos, Ninive Rangel, Karine Albuquerque, Yael Abreu‐Villaça, Érica Patrícia Garcia Souza, Celly Cristina Alves do Nascimento‐Saba,

Adipose Tissue and Metabolism

Cigarette smoking is worrisome in adults and also in adolescents. This study aim evaluates the influence of smoking in puberty and the consequences of withdrawal, body composition of female and male mice. At 35d mice were exposed to 3R4F cigarette smoke, 8 h/day for 15d (S, n =24).Then, half of animals were evaluated and the other half was maintained and evaluated thirty days after stop exposure (30d AS). An unexposed group accompanied the events (NS, n = 24). Body mass, body composition, food intake, blood, ipGTT and adipose tissue were evaluated. During exposure food intake was similar all groups, however, S groups showed low body mass gain. 30dAS, S groups increased body mass and food intake in females. In regard blood, males didi not alter insulin or ip GTT during exposure whilst females had high insulin levels and glycemia at 30min. Withdrawal induced in males, high insulin and low glycemia the ipGTT and in females normal insulin and low glycemia. The set of results indicates different response cigarette smoke in young that seem to start in females and lead malefic metabolic alterations in adulthood.