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Molecular epidemiological investigation of Mayaro virus in febrile patients from Goiania City, 2017–2018

2021; Elsevier BV; Volume: 95; Linguagem: Inglês

10.1016/j.meegid.2021.104981

1567-7257

Elisângela de Paula Silveira-Lacerda, Alice Laschuk Herlinger, Amílcar Tanuri, Giovanni Rezza, Carlos Eduardo Anunciação, Juliana Pires Ribeiro, Isabele Pereira Tannous, Gabrielly Regis Abrantes, Elisângela Gomes da Silva, Kauana Ferreira Arruda, Adriano Roberto Vieira de Sousa, Filipe Romero Rebello Moreira, Renato Santana Aguiar, Jordana Faria Corrêa, Marina Machado dos Santos, Hugo D. Silva, Marco Túlio Antônio García-Zapata, Natália Santana do Nascimento, Mariane Talon de Menezes, Richard Araújo Maia, Orlando Ferreira C., Rafael Inácio Barbosa, Rodrigo Brindeiro, Cléver Gomes Cardoso, Sandra Maria Brunini,

Vector-Borne Animal Diseases

Mayaro virus (MAYV) has historically been associated with sylvatic transmission; however, urban outbreaks have been reported in Brazil, including cases of co-detection with dengue virus (DENV). Therefore, we performed a molecular survey to investigate MAYV circulation and cocirculation with DENV within Goiania, a major city in Central-West Brazil. Among 375 subjects with arbovirus-like symptoms, 259 were positive for DENV and 26 for MAYV. Of these, 17 were coinfected with DENV-2, suggesting co-transmission of the viruses. The most common complaints at the time of inclusion were myalgia, headache, fever, arthralgia, retro-orbital pain, and skin rash. No specific symptoms were associated with MAYV when either detected alone or co-detected with DENV, compared to that when DENV was detected alone. Most MAYV-infected subjects were women with no recent travel history to rural/sylvatic areas. Phylogenetic reconstruction indicated that the MAYV identified in this study is closely related with a lineage observed in Peru, belonging to genotype D. Our results corroborate the growing circulation of MAYV in urban environments in Brazil and reinforce the need to implement laboratory diagnosis in the Unified Health System, considering that the clinical manifestations of Mayaro fever are similar to those of other arboviruses, particularly dengue. Furthermore, most cases occurred in association with DENV-2. Further phylogenetic studies are needed to evaluate MAYV, which has not been widely examined.