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Ultrapotent antibodies against diverse and highly transmissible SARS-CoV-2 variants

2021; American Association for the Advancement of Science; Volume: 373; Issue: 6556 Linguagem: Inglês

10.1126/science.abh1766

1095-9203

Lingshu Wang, Tongqing Zhou, Yi Zhang, Eun Sung Yang, Chaim A. Schramm, Wei Shi, Amarendra Pegu, Olamide K. Oloniniyi, Amy R. Henry, Samuel Darko, Sandeep Narpala, Christian Hatcher, David R. Martinez, Yaroslav Tsybovsky, Emily Phung, Olubukola M. Abiona, Avan Antia, Evan M. Cale, Lauren A. Chang, Misook Choe, Kizzmekia S. Corbett, Rachel L. Davis, Anthony DiPiazza, Ingelise J. Gordon, Sabrina Helmold Hait, Tandile Hermanus, Prudence Kgagudi, Farida Laboune, Kwanyee Leung, Tracy Liu, Rosemarie D. Mason, Alexandra F. Nazzari, Laura Novik, Sarah O’Connell, Sijy O’Dell, Adam S. Olia, Stephen D. Schmidt, Tyler Stephens, Christopher D. Stringham, Chloe Adrienna Talana, I‐Ting Teng, Danielle A. Wagner, Alicia T. Widge, Baoshan Zhang, Mario Roederer, Julie E. Ledgerwood, Tracy J. Ruckwardt, Martin R. Gaudinski, Penny L. Moore, Nicole A. Doria‐Rose, Ralph S. Baric, Barney S. Graham, Adrian B. McDermott, Daniel C. Douek, Peter D. Kwong, John R. Mascola, Nancy J. Sullivan, John Misasi,

vaccines and immunoinformatics approaches

Defenses against SARS-CoV-2 variants Our key defense against the COVID-19 pandemic is neutralizing antibodies against the SARS-CoV-2 virus elicited by natural infection or vaccination. Recent emerging viral variants have raised concern because of their potential to escape antibody neutralization. Wang et al . identified four antibodies from early-outbreak convalescent donors that are potent against 23 variants, including variants of concern, and characterized their binding to the spike protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Yuan et al . examined the impact of emerging mutations in the receptor-binding domain of the spike protein on binding to the host receptor ACE2 and to a range of antibodies. These studies may be helpful for developing more broadly effective vaccines and therapeutic antibodies. —VV