
Nanomedicine to deliver docosahexaenoic acid: potential applications to improve health
2021; Future Medicine; Volume: 16; Issue: 18 Linguagem: Italiano
10.2217/nnm-2021-0128
ISSN1748-6963
AutoresEduardo Burgarelli Lages, Gabriel Silva Marques Borges, Gisele Assis Castro Goulart, Lucas Antônio Miranda Ferreira,
Tópico(s)Cholesterol and Lipid Metabolism
ResumoNanomedicineVol. 16, No. 18 EditorialNanomedicine to deliver docosahexaenoic acid: potential applications to improve healthEduardo Burgarelli Lages‡, Gabriel Silva Marques Borges‡, Gisele Assis Castro Goulart & Lucas Antônio Miranda FerreiraEduardo Burgarelli Lages‡ https://orcid.org/0000-0002-2458-6021Departamento de Produtos Farmacêuticos, Faculdade de Farmácia, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil, Gabriel Silva Marques Borges‡ https://orcid.org/0000-0002-7360-8231Departamento de Produtos Farmacêuticos, Faculdade de Farmácia, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil, Gisele Assis Castro Goulart https://orcid.org/0000-0003-0292-076XDepartamento de Produtos Farmacêuticos, Faculdade de Farmácia, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil & Lucas Antônio Miranda Ferreira *Author for correspondence: E-mail Address: lucaufmg@gmail.comhttps://orcid.org/0000-0003-2474-5536Departamento de Produtos Farmacêuticos, Faculdade de Farmácia, Universidade Federal de Minas Gerais, Belo Horizonte, BrazilPublished Online:24 Jun 2021https://doi.org/10.2217/nnm-2021-0128AboutSectionsView ArticleView Full TextPDF/EPUB ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareShare onFacebookTwitterLinkedInReddit View articleKeywords: bioavailabilitydocosahexaenoic acidnanocarriersnanotechnologynutraceuticalsomega-3References1. McLennan P, Howe P, Abeywardena M et al. The cardiovascular protective role of docosahexaenoic acid. Eur. J. Pharmacol. 300(1-2), 83–89 (1996).Crossref, Medline, CAS, Google Scholar2. Riediger ND, Othman RA, Suh M, Moghadasian MH. A systemic review of the roles of n-3 fatty acids in health and disease. J. Am. Diet. Assoc. 109(4), 668–679 (2009).Crossref, Medline, CAS, Google Scholar3. Merendino N, Costantini L, Manzi L, Molinari R, D'Eliseo D, Velotti F. Dietary ω-3 polyunsaturated fatty acid DHA: a potential adjuvant in the treatment of cancer. Biomed Res. Int. 2013, 310186 (2013).Crossref, Medline, Google Scholar4. Endo J, Arita M. Cardioprotective mechanism of ω-3 polyunsaturated fatty acids. J. Cardiol. 67(1), 22–27 (2016).Crossref, Medline, Google Scholar5. Serini S, Vasconcelos RO, Gomes RN, Calviello G. Protective effects of ω-3 PUFA in anthracycline-induced cardiotoxicity: a critical review. Int. J. Mol. Sci. 18(12), 2689 (2017).Crossref, Google Scholar6. Lages EB, Fernandes RS, Silva J de O et al. Co-delivery of doxorubicin, docosahexaenoic acid, and α-tocopherol succinate by nanostructured lipid carriers has a synergistic effect to enhance antitumor activity and reduce toxicity. Biomed. Pharmacother. 132, 110876 (2020).Crossref, Medline, CAS, Google Scholar7. Lanna EG, Siqueira RP, Machado MGC et al. Lipid-based nanocarriers co-loaded with artemether and triglycerides of docosahexaenoic acid: effects on human breast cancer cells. Biomed. Pharmacother. 134, 111114 (2021).Crossref, Medline, CAS, Google Scholar8. Ismail A, Bannenberg G, Rice HB, Schutt E, Mackay D. Oxidation in EPA- and DHA-rich oils: an overview. Lipid Technol. 28(3-4), 55–59 (2016).Crossref, CAS, Google Scholar9. Bremmell KE, Briskey D, Meola TR, Mallard A, Prestidge CA, Rao A. A self-emulsifying Omega-3 ethyl ester formulation (AquaCelle) significantly improves eicosapentaenoic and docosahexaenoic acid bioavailability in healthy adults. Eur. J. Nutr. 59(6), 2729–2737 (2020).Crossref, Medline, CAS, Google Scholar10. Ghosh D, Singh SK, Khursheed R et al. Impact of solidification on micromeritic properties and dissolution rate of self-nanoemulsifying delivery system loaded with docosahexaenoic acid. Drug Dev. Ind. Pharm. 46(4), 597–605 (2020).Crossref, Medline, CAS, Google Scholar11. Hussey EK, Portelli S, Fossler MJ et al. Relative bioavailability of an emulsion formulation for omega-3-acid ethyl esters compared to the commercially available formulation: a randomized, parallel-group, single-dose study followed by repeat dosing in healthy volunteers. Clin. Pharmacol. Drug Dev. 1(1), 14–23 (2012).Crossref, Medline, CAS, Google Scholar12. Lopez-Toledano MA, Thorsteinsson T, Daak AA et al. Minimal food effect for eicosapentaenoic acid and docosahexaenoic acid bioavailability from omega-3-acid ethyl esters with an Advanced Lipid TechnologiesTM (ALT®)-based formulation. J. Clin. Lipidol. 11(2), 394–405 (2017).Crossref, Medline, Google Scholar13. Mussi SV, Silva RC, De Oliveira MC, Lucci CM, De Azevedo RB, Ferreira LAM. New approach to improve encapsulation and antitumor activity of doxorubicin loaded in solid lipid nanoparticles. Eur. J. Pharm. Sci. 48(1–2), 282–290 (2013).Crossref, Medline, CAS, Google Scholar14. Wang H, Lu Z, Wang L et al. New generation nanomedicines constructed from self-assembling small-molecule prodrugs alleviate cancer drug toxicity. Cancer Res. 77(24), 6963–6974 (2017).Crossref, Medline, CAS, Google Scholar15. Hilleman DE, Wiggins BS, Bottorff MB. Critical differences between dietary supplement and prescription omega-3 fatty acids: a narrative review. Adv. Ther. 37(2), 656–670 (2020).Crossref, Medline, CAS, Google Scholar16. Rasti B, Erfanian A, Selamat J. Novel nanoliposomal encapsulated omega-3 fatty acids and their applications in food. Food Chem. 230, 690–696 (2017).Crossref, Medline, CAS, Google Scholar17. Stark KD, Van Elswyk ME, Higgins MR, Weatherford CA, Salem N. Global survey of the omega-3 fatty acids, docosahexaenoic acid and eicosapentaenoic acid in the blood stream of healthy adults. Prog. Lipid Res. 63, 132–152 (2016).Crossref, Medline, CAS, Google Scholar18. Eltweri AM, Thomas AL, Fisk HL et al. Plasma and erythrocyte uptake of omega-3 fatty acids from an intravenous fish oil based lipid emulsion in patients with advanced oesophagogastric cancer. Clin. Nutr. 36(3), 768–774 (2017).Crossref, Medline, CAS, Google Scholar19. Bistrian BR. Parenteral fish-oil emulsions in critically ill COVID-19 emulsions. J. Parenter. Enter. Nutr. 44(7), 1168 (2020).Crossref, Medline, CAS, Google Scholar20. Franco MS, Oliveira MC. Ratiometric drug delivery using non-liposomal nanocarriers as an approach to increase efficacy and safety of combination chemotherapy. Biomed. Pharmacother. 96, 584–595 (2017).Crossref, Medline, CAS, Google Scholar21. Wang C, Wei X, Shao G. Functional doxorubicin-loaded omega-3 unsaturated fatty acids nanoparticles in reversing hepatocellular carcinoma multidrug resistance. Med. Sci. Monit. 27, e927727 (2020).Crossref, Google Scholar22. Guo P, Si M, Wu D, Xue HY, Hu W, Wong HL. Incorporation of docosahexaenoic acid (DHA) enhances nanodelivery of antiretroviral across the blood-brain barrier for treatment of HIV reservoir in brain. J. Control. Rel. 328, 696–709 (2020).Crossref, Medline, CAS, Google ScholarFiguresReferencesRelatedDetailsCited ByPharmaceutical nanoformulation strategies to spatiotemporally manipulate oxidative stress for improving cancer therapies — exemplified by polyunsaturated fatty acids and other ROS-modulating agents22 January 2022 | Drug Delivery and Translational Research, Vol. 12, No. 10pH-sensitive doxorubicin-tocopherol succinate prodrug encapsulated in docosahexaenoic acid-based nanostructured lipid carriers: An effective strategy to improve pharmacokinetics and reduce toxic effectsBiomedicine & Pharmacotherapy, Vol. 144 Vol. 16, No. 18 Follow us on social media for the latest updates Metrics Downloaded 55 times History Received 29 March 2021 Accepted 28 April 2021 Published online 24 June 2021 Published in print August 2021 Information© 2021 Future Medicine LtdKeywordsbioavailabilitydocosahexaenoic acidnanocarriersnanotechnologynutraceuticalsomega-3Financial & competing interests disclosureThis work was supported by the Brazilian agencies FAPEMIG (Fundação de Amparo à Pesquisa do Estado de Minas Gerais), CAPES (Coordenação de Aperfeiçoamento de Pessoal de Nível Superior) and CNPq (Conselho Nacional de Desenvolvimento Científico e Tecnológico). The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.No writing assistance was utilized in the production of this manuscript.PDF download
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