New CARs on and off the road: challenges and new developments in CAR-T cell therapy
2021; Elsevier BV; Volume: 59; Linguagem: Inglês
10.1016/j.coph.2021.05.005
ISSN1471-4973
Autores Tópico(s)Advancements in Semiconductor Devices and Circuit Design
ResumoBuilding on the tremendous success of chimeric antigen receptor T-cell therapy in hematological malignancies, there are efforts under way to overcome the challenges associated with this treatment and expand its application to solid tumors. In this fast-evolving field, new therapeutic options are constantly generated, tested in model systems, and further evaluated in clinical trials. In this review, we provide an overview of recent challenges and developments associated with engineered T cells and chimeric antigen receptor T-cell applications. We report on the most recent progress in hematological malignancies and highlight technical advances for applications in solid tumors.
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