Portal de Periódicos da CAPES

Artigo Produção Nacional Revisado por pares

BIBTEX RIS

Effects of dietary supplementation with fish oil on cutaneous wound healing of stressed mice

2013; Wiley; Volume: 27; Issue: S1 Linguagem: Inglês

10.1096/fasebj.27.1_supplement.754.6

1530-6860

Bruna Romana‐Souza, Alice dos Santos Rosa, Luana Gabriela Bandeira, Andréa Monte‐Alto‐Costa,

Wound Healing and Treatments

Neither study demonstrated if supplementation with fish oil could inhibit stress effects on cutaneous wound healing. Thus, the aim of this study was to investigate effect of fish oil supplementation on cutaneous wound healing of chronically stressed mice. Adult male mice (n=10 per group) were daily spun at 115 rpm for 15 minutes every hour until euthanasia. Other animals were not submitted to stress. Fish oil administration began one day before wounding and was continued daily until euthanasia. A full‐thickness excisional lesion was performed. Fourteen days later, animals were killed and lesions were collected. This study was approved by the Ethical Commission in the Research of the Federal Rural University of Rio de Janeiro (n°095/2010). Fish oil administration did not inhibit stress‐induced reduction in wound contraction and hydroxyproline levels. Stress‐induced increase in F4/80‐positive macrophage, MPO‐positive neutrophil number, and α‐SMA‐positive myofibroblast density was not reversed by fish oil. However, fish oil administration reversed stress‐induced increase in catecholamine and PGE 2 levels. In conclusion, although supplementation with fish oil reversed the effects of stress on catecholamine and PGE 2 synthesis it did not improve cutaneous wound healing of stressed mice. This study was supported by the Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro (FAPERJ).