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Exhaled volatilome analysis as a useful tool to discriminate asthma with other coexisting atopic diseases in women of childbearing age

2021; Nature Portfolio; Volume: 11; Issue: 1 Linguagem: Inglês

10.1038/s41598-021-92933-2

2045-2322

Rosa Alba Sola Martínez, Gema Lozano Terol, Julia Gallego‐Jara, Eva Morales, Esther Cantero‐Cano, Manuel Sánchez‐Solís, Luis García‐Marcos, Pedro Jiménez‐Guerrero, José Antonio Noguera Velasco, Manuel Cánovas, Teresa De Diego, M. E. Candel-Torralba, Luis García‐Marcos, M. J. Gimenez-Banon, Antonia E. Martinez‐Torres, Eva Morales, Virginia Pérez‐Fernández, Manuel Sánchez‐Solís, Aníbal Nieto Díaz, María T. Prieto‐Sánchez, María Luisa Sánchez-Ferrer, L. Fernández-Palacios, V. P. Gomez-Gomez, Carmen Martínez‐Graciá, Patricia Peso‐Echarri, G. Ros-Berruezo, Marina Santaella, Antonio Gázquez, Elvira Larqué, M. T. Pastor-Fajardo, María Sánchez-Campillo, A. Serrano-Munuera, Matilde Zornoza‐Moreno, Pedro Jiménez‐Guerrero, E. Adomnei, J. J. Arense-Gonzalo, Jaime Mendiola, F. Navarro-Lafuente, Alberto M. Torres‐Cantero, C. Salvador-Garcia, M. Segovia-Hernández, Genoveva Yagüe‐Guirao, P. L. Valero-Guillén, F. V. Aviles-Plaza, Juan Cabezas‐Herrera, A. Martinez-Lopez, Miriam Martínez-Villanueva, José Antonio Noguera Velasco, Esther Cantero‐Cano, A. Franco-Garcia, A. M. Garcia-Serna, Trinidad Hernández‐Caselles, Elena Martín‐Orozco, M. Norte-Muñoz, Manuel Cánovas, Teresa De Diego, J. M. Pastor, R. A. Sola-Martínez, A. Esteban-Gil, Jesualdo Tomás Fernández‐Breis, M. V. Alcántara, Sandra Hernández, Concepción López Soler,

Asthma and respiratory diseases

The prevalence of asthma is considerably high among women of childbearing age. Most asthmatic women also often have other atopic disorders. Therefore, the differentiation between patients with atopic diseases without asthma and asthmatics with coexisting diseases is essential to avoid underdiagnosis of asthma and to design strategies to reduce symptom severity and improve quality of life of patients. Hence, we aimed for the first time to conduct an analysis of volatile organic compounds in exhaled breath of women of childbearing age as a new approach to discriminate between asthmatics with other coexisting atopic diseases and non-asthmatics (with or without atopic diseases), which could be a helpful tool for more accurate asthma detection and monitoring using a noninvasive technique in the near future. In this study, exhaled air samples of 336 women (training set (n = 211) and validation set (n = 125)) were collected and analyzed by thermal desorption coupled with gas chromatography-mass spectrometry. ASCA (ANOVA (analysis of variance) simultaneous component analysis) and LASSO + LS (least absolute shrinkage and selection operator + logistic regression) were employed for data analysis. Fifteen statistically significant models (p-value < 0.05 in permutation tests) that discriminated asthma with other coexisting atopic diseases in women of childbearing age were generated. Acetone, 2-ethyl-1-hexanol and a tetrahydroisoquinoline derivative were selected as discriminants of asthma with other coexisting atopic diseases. In addition, carbon disulfide, a tetrahydroisoquinoline derivative, 2-ethyl-1-hexanol and decane discriminated asthma disease among patients with other atopic disorders. Results of this study indicate that refined metabolomic analysis of exhaled breath allows asthma with other coexisting atopic diseases discrimination in women of reproductive age.