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Is severe COVID-19 a cytokine storm syndrome: a hyperinflammatory debate

2021; Lippincott Williams & Wilkins; Volume: 33; Issue: 5 Linguagem: Inglês

10.1097/bor.0000000000000822

1531-6963

Puja Mehta, David C. Fajgenbaum,

Inflammasome and immune disorders

The COVID-19 pandemic is a global public health crisis with considerable mortality and morbidity. A role for cytokine storm and therapeutic immunomodulation in a subgroup of patients with severe COVID-19 was proposed early in the pandemic. The concept of cytokine storm in COVID-19 has been criticised, given the lack of clear definition and relatively modest cytokinaemia (which may be necessary for viral clearance) compared with acute respiratory distress syndrome and bacterial sepsis. Here we consider the arguments for and against the concept of cytokine storm in COVID-19.