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Danish national guideline for the treatment of Clostridioides difficile infection and use of faecal microbiota transplantation (FMT)

2021; Taylor & Francis; Volume: 56; Issue: 9 Linguagem: Inglês

10.1080/00365521.2021.1922749

1502-7708

Simon Mark Dahl Baunwall, Jens Frederik Dahlerup, Jørgen Engberg, Christian Erikstrup, Morten Helms, Mie Agerbæk Juel, Jens Kjeldsen, Hans Linde Nielsen, Anna Christine Nilsson, Anne Rode, Lars Vinter‐Jensen, Christian Lodberg Hvas,

Gut microbiota and health

Aim: This Danish national guideline describes the treatment of adult patients with Clostridioides (formerly Clostridium) difficile (CD) infection and the use of faecal microbiota transplantation (FMT). It suggests minimum standard for implementing an FMT service.Method: Four scientific societies appointed members for a working group which conducted a systematic literature review and agreed on the text and recommendations. All clinical recommendations were evalluated for evidence level and grade of recommendation.Results: In CD infection, the use of marketed and experimental antibiotics as well as microbiota-based therapies including FMT are described. An algorithm for evaluating treatment effect is suggested. The organisation of FMT, donor recruitment and screening, laboratory preparation, clinical application and follow-up are described.Conclusion: Updated evidence for the treatment of CD infection and the use of FMT is provided.