Produção Nacional
Revisado por pares
Maternal outcomes and risk factors for COVID-19 severity among pregnant women
2021; Nature Portfolio; Volume: 11; Issue: 1 Linguagem: Inglês
10.1038/s41598-021-92357-y
ISSN2045-2322
AutoresManon Vouga, Guillaume Favre, Óscar Martínez Pérez, Léo Pomar, Laura Forcén Acebal, Alejandra Abascal-Saiz, Marı́a Rosa Hernández, Najeh Hcini, Véronique Lambert, Gabriel Carles, Joanna Sichitiu, Laurent Salomon, J. Stirnemann, Y. Ville, Begoña Martínez de Tejada, Anna Goncé, Ameth Hawkins-Villarreal, K. Castillo, E. Gratacós, Lucas Trigo, Brian Cleary, Michael Geary, Helena C. Bartels, Feras Al-Kharouf, Fergal D. Malone, Mary Higgins, Niamh Keating, Susan Knowles, C. Poncelet, Carolina C. Ribeiro‐do‐Valle, Fernanda Garanhani Surita, Amanda Dantas‐Silva, Carolina Bicudo Borrelli, Adriana Gomes Luz, Javiera Fuenzalida, Jorge Carvajal C, Manuel Guerra Canales, Olivia Allende Hernández, Olga Grechukhina, Albert I. Ko, Uma M. Reddy, Rita Figueiredo, Marina Moucho, Pedro Viana Pinto, Carmen De Luca, Marco De Santis, Diogo Ayres‐de‐Campos, Inês Martins, Charles Garabédian, D. Subtil, Betânia Barreto de Athayde Bohrer, Maria Oppermann, Maria Celeste Osório Wender, Lavínia Schüler‐Faccini, Maria Teresa Vieira Sanseverino, Camila Giugliani, Luciana Friedrich, Mariana Horn Scherer, Nicolas Mottet, Guillaume Ducarme, Hélène Pelerin, Chloé Moreau, Bénédicte Breton, T. Quibel, Patrick Rozenberg, Éric Giannoni, Cristina Granado, Cécile Monod, D Mueller, Irène Hoesli, Dirk Bassler, Sandra A. Heldstab, Nicole Ochsenbein‐Kölble, Loı̈c Sentilhes, Melissa Charvet, Jan Deprest, Jute Richter, Lennart Van der Veeken, Béatrice Eggel-Hort, Gaëtan Plantefève, Mohamed Derouich, Álbaro Jose Nieto‐Calvache, María Camila López-Girón, Juan Manuel Burgos‐Luna, María Fernanda Escobar-Vidarte, Kurt Hecher, Ann‐Christin Tallarek, Eran Hadar, Karina Krajden Haratz, Uri Amikam, G. Malinger, Ron Maymon, Yariv Yogev, Leonhard Schäffer, Arnaud Toussaint, Marie-Claude Rossier, Renato Augusto Moreira de Sá, Claudia Grawe, Karoline Aebi‐Popp, Anda‐Petronela Radan, Luigi Raio, Daniel Surbek, Paul Böckenhoff, Brigitte Strizek, Martin Kaufmann, Andrea Bloch, Michel Boulvain, Silke Johann, Sandra A. Heldstab, Monya Todesco Bernasconi, Gastón Grant, Anis Féki, Anne-Claude Müller Brochut, Marylene Giral, Lucie Sedille, Andrea Papadia, Romina Capoccia Brugger, Brigitte Weber, Tina Fischer, Christian R. Kahlert, Karin Nielsen Saines, Mary Catherine Cambou, P. Kanellos, Xiang Chen, Mingzhu Yin, Annina Haessig, Sandrine Ackermann, David Baud, Alice Panchaud,
Tópico(s)Maternal and fetal healthcare
ResumoPregnant women may be at higher risk of severe complications associated with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which may lead to obstetrical complications. We performed a case control study comparing pregnant women with severe coronavirus disease 19 (cases) to pregnant women with a milder form (controls) enrolled in the COVI-Preg international registry cohort between March 24 and July 26, 2020. Risk factors for severity, obstetrical and immediate neonatal outcomes were assessed. A total of 926 pregnant women with a positive test for SARS-CoV-2 were included, among which 92 (9.9%) presented with severe COVID-19 disease. Risk factors for severe maternal outcomes were pulmonary comorbidities [aOR 4.3, 95% CI 1.9-9.5], hypertensive disorders [aOR 2.7, 95% CI 1.0-7.0] and diabetes [aOR2.2, 95% CI 1.1-4.5]. Pregnant women with severe maternal outcomes were at higher risk of caesarean section [70.7% (n = 53/75)], preterm delivery [62.7% (n = 32/51)] and newborns requiring admission to the neonatal intensive care unit [41.3% (n = 31/75)]. In this study, several risk factors for developing severe complications of SARS-CoV-2 infection among pregnant women were identified including pulmonary comorbidities, hypertensive disorders and diabetes. Obstetrical and neonatal outcomes appear to be influenced by the severity of maternal disease.
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