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Antimicrobial and antioxidant activities of secondary metabolites from endophytic fungus Botryosphaeria fabicerciana (MGN23-3) associated to Morus nigra L

2021; Taylor & Francis; Volume: 36; Issue: 12 Linguagem: Inglês

10.1080/14786419.2021.1947272

1478-6427

Angela Aparecida da Silva, Júlio César Polonio, Aline Maria Bulla, Andressa Domingos Polli, Juliana Cristina Castro, Lilian Capelari Soares, Verci Alves de Oliveira, Verônica Elisa Pimenta Vicentini, Arildo José Braz de Oliveira, José Eduardo Gonçalves, Regina Aparecida Correia Gonçalves, João Lúcio de Azevedo, Benício Alves de Abreu Filho, João Alencar Pamphile,

Microbial Natural Products and Biosynthesis

This study was to evaluate the biological activity of the extract of Botryosphaeria fabicerciana isolated from leaves of Morus nigra. The volatile compounds from the crude extract were analysed by GC-MS which demonstrate that mellein and β-orcinaldehyde were are the major compounds. The best minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) of the extract was observed against Gram-positive bacteria, with a MIC of 15.6 μg/mL towards B. cereus and MIC of 62.5 μg/mL towards S. aureus and B. subtilis. MBC values of 31.25 μg/mL, 62.5 μg/mL, and 250 μg/mL were observed towards B. cereus, B. subtilis, and S. aureus, respectively. The cytotoxicity analyses showed CC50 of 115 μg/mL. The crude extract showed antioxidant activity by the DPPH, ABTS, and FRAP assays. Therefore, the extract of the endophytic fungus presented biotechnological potential as an antibacterial and antioxidant agent.