Portal de Periódicos da CAPES

Kinetic Aspects of Disease Suppression by Apoptosis

2019; RELX Group (Netherlands); Linguagem: Inglês

10.2139/ssrn.3438654

1556-5068

Roger Highmore,

Computational Drug Discovery Methods

Externally-signalled apoptosis has been characterised as a “travelling wave of cell death” and its (finite) speed has been measured. This suggests the possibility of a kinetic contest or race between, on the one hand, the “wave of cell death” apoptosis front and, on the other hand, growing clusters of diseased cells. Diseased cells will be eliminated, and disease suppressed, provided the apoptosis front advances faster than the diseased clusters can grow.Diseased cells will be more likely to outrun the apoptosis front and so become established in an organism if they can perform an initial, rapid growth ‘sprint’. Cancer cells may gain dynamism for such an initial growth spurt by deriving energy from aerobic glycolysis rather than oxidative phosphorylation.