Cordyceps polysaccharide marker CCP modulates immune responses via highly selective TLR4/MyD88/p38 axis
2021; Elsevier BV; Volume: 271; Linguagem: Inglês
10.1016/j.carbpol.2021.118443
ISSN1879-1344
AutoresQuanwei Zhang, Man Liu, Lifeng Li, Miaomiao Chen, Pema Tenzin Puno, Wan-Rong Bao, Hongming Zheng, Xin Wen, Huiyuan Cheng, Hau-Yee Fung, Tin-Long Wong, Zhongzhen Zhao, Aiping Lyu, Quan‐Bin Han, Han‐Dong Sun,
Tópico(s)Herbal Medicine Research Studies
ResumoCordyceps, one of the most expensive natural health supplements, is popularly used to modulate immune function. However, little is known regarding the underlying mechanism of its immunomodulatory activity. We newly reported a Cordyceps quality marker CCP (Mw 433.778 kDa) which was characterized as a 1,4-α glucan by chemical and spectral analysis and is able to induce significant immune responses of macrophages. Herein, we further investigated the molecular mechanism of CCP's immunomodulatory effects. The results indicate that CCP modulates the TLR4/MyD88/p38 signaling pathway of macrophages, where TLR4 plays a crucial role as verified on TLR4-deficient (TLR4-/-) bone marrow-derived macrophages (BMDMs) and TLR4-/- mice. These findings provide a precise understanding of the molecular mechanism of Cordyceps' immunomodulatory benefits.
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