Elevated urinary mutagenicity among those exposed to bituminous coal combustion emissions or diesel engine exhaust
2021; Wiley; Volume: 62; Issue: 8 Linguagem: Inglês
10.1002/em.22455
ISSN1098-2280
AutoresJason Y.Y. Wong, Roel Vermeulen, Yufei Dai, Wei Hu, W. Kyle Martin, Sarah H. Warren, Hannah K. Liberatore, Dianzhi Ren, Huawei Duan, Yong Niu, Jun Xu, Wei Fu, Kees Meliefste, Jufang Yang, Meng Ye, Xiaowei Jia, Tao Meng, Bryan A. Bassig, H. Dean Hosgood, Jiyeon Choi, Mohammad L. Rahman, Douglas I. Walker, Yuxin Zheng, Judy L. Mumford, Debra T. Silverman, Nathaniel Rothman, David M. DeMarini, Qing Lan,
Tópico(s)Toxic Organic Pollutants Impact
ResumoUrinary mutagenicity reflects systemic exposure to complex mixtures of genotoxic/carcinogenic agents and is linked to tumor development. Coal combustion emissions (CCE) and diesel engine exhaust (DEE) are associated with cancers of the lung and other sites, but their influence on urinary mutagenicity is unclear. We investigated associations between exposure to CCE or DEE and urinary mutagenicity. In two separate cross-sectional studies of nonsmokers, organic extracts of urine were evaluated for mutagenicity levels using strain YG1041 in the Salmonella (Ames) mutagenicity assay. First, we compared levels among 10 female bituminous (smoky) coal users from Laibin, Xuanwei, China, and 10 female anthracite (smokeless) coal users. We estimated exposure-response relationships using indoor air concentrations of two carcinogens in CCE relevant to lung cancer, 5-methylchrysene (5MC), and benzo[a]pyrene (B[a]P). Second, we compared levels among 20 highly exposed male diesel factory workers and 15 unexposed male controls; we evaluated exposure-response relationships using elemental carbon (EC) as a DEE-surrogate. Age-adjusted linear regression was used to estimate associations. Laibin smoky coal users had significantly higher average urinary mutagenicity levels compared to smokeless coal users (28.4 ± 14.0 SD vs. 0.9 ± 2.8 SD rev/ml-eq, p = 2 × 10
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