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Platforms for Production of Protein-Based Vaccines: From Classical to Next-Generation Strategies

2021; Multidisciplinary Digital Publishing Institute; Volume: 11; Issue: 8 Linguagem: Inglês

10.3390/biom11081072

2218-273X

Raquel Cid, Jorge Bolı́var,

Viral Infectious Diseases and Gene Expression in Insects

To date, vaccination has become one of the most effective strategies to control and reduce infectious diseases, preventing millions of deaths worldwide. The earliest vaccines were developed as live-attenuated or inactivated pathogens, and, although they still represent the most extended human vaccine types, they also face some issues, such as the potential to revert to a pathogenic form of live-attenuated formulations or the weaker immune response associated with inactivated vaccines. Advances in genetic engineering have enabled improvements in vaccine design and strategies, such as recombinant subunit vaccines, have emerged, expanding the number of diseases that can be prevented. Moreover, antigen display systems such as VLPs or those designed by nanotechnology have improved the efficacy of subunit vaccines. Platforms for the production of recombinant vaccines have also evolved from the first hosts,