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Breast and Prostate Cancer Risks for Male BRCA1 and BRCA2 Pathogenic Variant Carriers Using Polygenic Risk Scores

2021; Oxford University Press; Volume: 114; Issue: 1 Linguagem: Inglês

10.1093/jnci/djab147

1460-2105

Daniel R. Barnes, Valentina Silvestri, Goska Leslie, Lesley McGuffog, Joe Dennis, Xin Yang, Julian Adlard, Bjarni A. Agnarsson, Munaza Ahmed, Kristiina Aittomäki, Irene L. Andrulis, Aðalgeir Arason, Norbert Arnold, Bernd Auber, Jacopo Azzollini, Judith Balmañà, Rósa B. Barkardóttir, Daniel Barrowdale, Julian Barwell, Muriel Belotti, Javier Benı́tez, Pascaline Berthet, Susanne E. Boonen, Åke Borg, Anikó Bozsik, Angela F. Brady, Paul Brennan, Carole Brewer, Joan Brunet, Agostino Bucalo, Saundra S. Buys, Trinidad Caldés, Maria A. Caligo, Ian Campbell, Hayley Cassingham, Lise Lotte Christensen, Giulia Cini, Kathleen Claes, Jackie Cook, Anna Coppa, Laura Cortesi, Giuseppe Damante, Esther Darder, Rosemarie Davidson, Miguel de la Hoya, Kim De Leeneer, Robin De Putter, Jesús Del Valle, Orland Dı́ez, Yuan Chun Ding, Susan M. Domchek, Alan Donaldson, Jacqueline Eason, Rosalind A. Eeles, Christoph Engel, D. Gareth Evans, Lídia Feliubadaló, Florentia Fostira, Megan N. Frone, Debra Frost, David Gallagher, Andrea Gehrig, Sophie Giraud, Gord Glendon, Andrew K. Godwin, David E. Goldgar, Mark H. Greene, Helen Gregory, Eva Groß, Eric Hahnen, Ute Hamann, Thomas van Overeem Hansen, Helen Hanson, Julia Hentschel, Judit Horváth, Louise Izatt, À. Izquierdo, Paul A. James, Ramūnas Janavičius, Uffe Birk Jensen, Oskar T. Johannsson, Esther M. John, Gero Kramer, Lone Kroeldrup, Torben A. Kruse, Charlotte Kvist Lautrup, Conxi Lázaro, Fabienne Lesueur, Adrià López‐Fernández, L. Phuong, Siranoush Manoukian, Zoltán Mátrai, Laura Matricardi, Kara N. Maxwell, Noura Mebirouk, Alfons Meindl, Marco Montagna, Álvaro N.A. Monteiro, Patrick J. Morrison, Taru Muranen, Alex Murray, Katherine L. Nathanson, Susan L. Neuhausen, Heli Nevanlinna, Tú Nguyen‐Dumont, Dieter Niederacher, Edith Oláh, Olufunmilayo I. Olopade, Domenico Palli, Michael T. Parsons, Inge Søkilde Pedersen, Bernard Peissel, Pedro Pérez‐Segura, Paolo Peterlongo, Annabeth Høgh Petersen, Pedro Pinto, Mary Porteous, Caroline Pottinger, Miquel Angel Pujana, Paolo Radice, Juliane Ramser, Johanna Rantala, Mark E. Robson, Mark T. Rogers, Karina Rønlund, Andreas Rump, A.M. SÁnchez De Abajo, Payal D. Shah, Saba Sharif, Lucy Side, Christian F. Singer, Zsofia Stadler, Linda Steele, Dominique Stoppa‐Lyonnet, Christian Sutter, Yen Y. Tan, Manuel R. Teixeira, Àlex Teulé, Darcy L. Thull, Marc Tischkowitz, Amanda E. Toland, Stefania Tommasi, Angela Toss, Alison H. Trainer, Vishakha Tripathi, Virginia Valentini, Christi J. van Asperen, Marta Venturelli, Alessandra Viel, Joseph Vijai, Lisa Walker, Shan Wang‐Gohrke, Barbara Wappenschmidt, Anna Whaite, Ines Zanna, Kenneth Offit, Mads Thomassen, Fergus J. Couch, Rita K. Schmutzler, Jacques Simard, Douglas F. Easton, Georgia Chenevix‐Trench, Antonis C. Antoniou, Laura Ottini,

PARP inhibition in cancer therapy

Recent population-based female breast cancer and prostate cancer polygenic risk scores (PRS) have been developed. We assessed the associations of these PRS with breast and prostate cancer risks for male BRCA1 and BRCA2 pathogenic variant carriers.