Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection
2021; Springer Nature; Volume: 18; Issue: 9 Linguagem: Inglês
10.1038/s41423-021-00728-2
ISSN2042-0226
AutoresAlberto Pérez‐Gómez, Joana Vitallé, Carmen Gasca‐Capote, Alicia Gutiérrez‐Valencia, María Trujillo‐Rodríguez, Ana Serna‐Gallego, Esperanza Muñoz‐Muela, María de los Reyes Jiménez-Leon, Mohammed Rafii‐El‐Idrissi Benhnia, Inmaculada Rivas‐Jeremías, César Sotomayor, Cristina Roca-Oporto, Núria Espinosa, Carmen Infante-Domínguez, Juan Carlos Crespo‐Rivas, Alberto Fernández‐Villar, Alexandre Pérez‐González, Luís F. López‐Cortés, Eva Poveda, Ezequiel Ruiz‐Mateos, José Miguel Cisneros, Sonsoles Salto‐Alejandre, Judith Berastegui‐Cabrera, Pedro Camacho‐Martínez, Carmen Infante-Domínguez, Marta Carretero-Ledesma, Juan Carlos Crespo‐Rivas, Eduardo Márquez Martín, José Manuel Lomas, Claudio Bueno, Rosario Amaya, José Antonio Lepe, Jerónimo Pachón, Elisa Cordero, Javier Sánchez‐Céspedes, Manuela Aguilar‐Guisado, Almudena Aguilera, Clara Aguilera, T. Aldabó-Pallás, Verónica Alfaro‐Lara, Cristina Amodeo, Javier Ampuero, María Dolores Avilés, Maribel Asensio, Bosco Barón‐Franco, L. Barrera Pulido, Rafael Bellido-Alba, Máximo Bernabéu-Wittel, Candela Caballero‐Eraso, Macarena Cabrera‐Serrano, Enrique J. Calderón, J. Carbajal-Guerrero, Manuela Cid-Cumplido, Y. Corcia-Palomo, Juan Delgado, Antonio Domínguez-Petit, Alejandro Deniz, Reginal Dusseck-Brutus, Ana Escoresca‐Ortega, Núria Espinosa, Núria Espinosa, Michelle Espinoza, Carmen Ferrándiz‐Millón, Marta Ferrer‐García, Teresa Ferrer, Ignacio Gallego-Texeira, Rosa Gámez-Mancera, Emilio Gutiérrez, Horacio García-Delgado, Manuel García‐Gutiérrez, María Luisa Gascón-Castillo, Aurora González-Estrada, Demetrio González, Carmen Gómez-González, Rocío González-León, Carmen Grande-Cabrerizo, Sonia Gutiérrez, Carlos Hernández-Quiles, Inmaculada Concepción Herrera-Melero, Marta Herrero, Luis Jara‐Palomares, Carlos Jiménez-Juan, Silvia Jiménez‐Jorge, Mercedes Jiménez-Sánchez, Julia Lanseros-Tenllado, Carmina López, Isabel López, Álvaro López-Barrios, Luís F. López‐Cortés, Rafael Luque‐Márquez, Daniel Macías‐García, Guillermo Martín-Gutiérrez, Luis Martín-Villén, Jose Miguel Rodriguez Molina, Aurora Fernández‐Cañadas Morillo, María Dolores Navarro-Amuedo, Dolores Nieto-Martín, Francisco Órtega Ruiz, María Paniagua‐García, Amelia Peña-Rodríguez, Esther Pérez‐Herrán, Manuel Poyato Borrego, Julia Praena‐Segovia, Rafaela Ríos, Cristina Roca-Oporto, Jesús Flores Rodríguez, María Jesús Rodríguez-Hernández, Santiago Rodríguez-Suárez, Ángel Rodríguez-Villodres, Nieves Romero-Rodríguez, Ricardo Ruiz, Zida Ruiz de Azua, Celia Salamanca, Sonia Sánchez, Víctor Manuel Sánchez-Montagut, César Sotomayor, A. Suarez, Javier Toral,
Tópico(s)COVID-19 Clinical Research Studies
ResumoSevere Acute Respiratory Syndrome Coronavirus (SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components. Dendritic cells (DCs) play a key role in the defense against viral infections, for instance plasmacytoid DCs (pDCs), have the capacity to produce vast amounts of interferon-alpha (IFN-α). In COVID-19 there is a deficit in DC numbers and IFN-α production, which has been associated with disease severity. In this work, we described that in addition to the DC deficiency, several DC activation and homing markers were altered in acute COVID-19 patients, which were associated with multiple inflammatory markers. Remarkably, previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+ myeloid DCs and pDCs seven months after SARS-CoV-2 infection. Moreover, the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients, while no restoration of integrin β7 and indoleamine 2,3-dyoxigenase (IDO) levels were observed. These findings contribute to a better understanding of the immunological sequelae of COVID-19.
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