FUS-ALS mutants alter FMRP phase separation equilibrium and impair protein translation
2021; American Association for the Advancement of Science; Volume: 7; Issue: 30 Linguagem: Inglês
10.1126/sciadv.abf8660
ISSN2375-2548
AutoresNicol Birsa, Agnieszka M Ule, Maria Giovanna Garone, Brian Tsang, Francesca Mattedi, P. Andrew Chong, Jack Humphrey, Seth Jarvis, Melis Pisiren, Oscar G. Wilkins, Micheal L. Nosella, Anny Devoy, Cristian Bodo, Rafaela Fernandez de la Fuente, Elizabeth Fisher, Alessandro Rosa, Gabriella Viero, Julie D. Forman‐Kay, Giampietro Schiavo, Pietro Fratta,
Tópico(s)Genetics and Neurodevelopmental Disorders
ResumoCytoplasmic mislocalization of FUS-ALS mutants determines aberrant FMRP condensates and protein synthesis repression.
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