The key role of aquaporins in animals and plants
2021; Elsevier BV; Volume: 188; Linguagem: Inglês
10.1016/j.biochi.2021.07.007
ISSN1638-6183
Autores Tópico(s)Ion Transport and Channel Regulation
ResumoThe human colon balances water and electrolyte absorption and secretion while also forming a barrier protecting the body from the entry of harmful components. Aquaporin-3 (AQP3) is a water, glycerol and H2O2 transporting channel expressed in colonic epithelia. Although expression of colonic epithelial AQP3 is altered in several intestinal disorders, such as inflammatory bowel disease and irritable bowel syndrome, the regulation and specific roles of AQP3 remain to be fully defined. In this mini-review, we summarize the current understanding of the expression, regulation, and biological functions of AQP3 protein in colonic epithelia concerning intestinal absorption, secretion and barrier function.
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