Serum miR‐224, miR‐760, miR‐483‐5p, miR‐378 and miR‐375 as potential novel biomarkers in rheumatoid arthritis
2021; Wiley; Volume: 75; Issue: 11 Linguagem: Inglês
10.1111/ijcp.14651
ISSN1742-1241
AutoresOmayma O. Abdelaleem, Nermeen Ahmed Fouad, Olfat Shaker, Tarek I. Ahmed, Noha K. Abdelghaffar, Hanaa H. Eid, Abdelrahmaan A. Mohamed, Ahmed Elebiary, Mohamed Mokhtar Mohamed, Rania H. Mahmoud,
Tópico(s)Cancer-related molecular mechanisms research
ResumoInternational Journal of Clinical PracticeVolume 75, Issue 11 e14651 ORIGINAL PAPER Serum miR-224, miR-760, miR-483-5p, miR-378 and miR-375 as potential novel biomarkers in rheumatoid arthritis Omayma O. Abdelaleem, Corresponding Author Omayma O. Abdelaleem dr.omayma@yahoo.com orcid.org/0000-0003-2881-6776 Department of Medical Biochemistry and Molecular Biology, Faculty of Medicine, Fayoum University, Fayoum, Egypt Correspondence Omayma O. Abdelaleem, Medical Biochemistry and Molecular Biology, Faculty of Medicine, Fayoum University, Fayoum, Egypt Email address: dr.omayma@yahoo.comSearch for more papers by this authorNermeen A. Fouad, Nermeen A. Fouad Department of Rheumatology and Rehabilitation, Faculty of Medicine, Fayoum University, Fayoum, EgyptSearch for more papers by this authorOlfat G. Shaker, Olfat G. Shaker Department of Biochemistry and molecular biology, Faculty of Medicine, Cairo University, Cairo, EgyptSearch for more papers by this authorTarek I. Ahmed, Tarek I. Ahmed Department of Internal medicine, Faculty of Medicine, Fayoum University, Fayoum, EgyptSearch for more papers by this authorNoha K. Abdelghaffar, Noha K. Abdelghaffar Department of clinical pathology, Faculty of Medicine, Fayoum University, Fayoum, EgyptSearch for more papers by this authorHanaa M. Eid, Hanaa M. Eid Department of Medical microbiology and immunology, Faculty of Medicine, Fayoum University, Fayoum, EgyptSearch for more papers by this authorAbdelrahmaan A. Mohamed, Abdelrahmaan A. Mohamed Department of Medical microbiology and immunology, Faculty of Medicine, Fayoum University, Fayoum, EgyptSearch for more papers by this authorAhmed Magdy Elebiary, Ahmed Magdy Elebiary Department of Medical physiology, Faculty of Medicine, Fayoum University, Fayoum, EgyptSearch for more papers by this authorMohamed M. Mohamed, Mohamed M. Mohamed Department of Internal medicine, Faculty of Medicine, Cairo University, Cairo, EgyptSearch for more papers by this authorRania H. Mahmoud, Rania H. Mahmoud Department of Medical Biochemistry and Molecular Biology, Faculty of Medicine, Fayoum University, Fayoum, EgyptSearch for more papers by this author Omayma O. Abdelaleem, Corresponding Author Omayma O. Abdelaleem dr.omayma@yahoo.com orcid.org/0000-0003-2881-6776 Department of Medical Biochemistry and Molecular Biology, Faculty of Medicine, Fayoum University, Fayoum, Egypt Correspondence Omayma O. Abdelaleem, Medical Biochemistry and Molecular Biology, Faculty of Medicine, Fayoum University, Fayoum, Egypt Email address: dr.omayma@yahoo.comSearch for more papers by this authorNermeen A. Fouad, Nermeen A. Fouad Department of Rheumatology and Rehabilitation, Faculty of Medicine, Fayoum University, Fayoum, EgyptSearch for more papers by this authorOlfat G. Shaker, Olfat G. Shaker Department of Biochemistry and molecular biology, Faculty of Medicine, Cairo University, Cairo, EgyptSearch for more papers by this authorTarek I. Ahmed, Tarek I. Ahmed Department of Internal medicine, Faculty of Medicine, Fayoum University, Fayoum, EgyptSearch for more papers by this authorNoha K. Abdelghaffar, Noha K. Abdelghaffar Department of clinical pathology, Faculty of Medicine, Fayoum University, Fayoum, EgyptSearch for more papers by this authorHanaa M. Eid, Hanaa M. Eid Department of Medical microbiology and immunology, Faculty of Medicine, Fayoum University, Fayoum, EgyptSearch for more papers by this authorAbdelrahmaan A. Mohamed, Abdelrahmaan A. Mohamed Department of Medical microbiology and immunology, Faculty of Medicine, Fayoum University, Fayoum, EgyptSearch for more papers by this authorAhmed Magdy Elebiary, Ahmed Magdy Elebiary Department of Medical physiology, Faculty of Medicine, Fayoum University, Fayoum, EgyptSearch for more papers by this authorMohamed M. Mohamed, Mohamed M. Mohamed Department of Internal medicine, Faculty of Medicine, Cairo University, Cairo, EgyptSearch for more papers by this authorRania H. Mahmoud, Rania H. Mahmoud Department of Medical Biochemistry and Molecular Biology, Faculty of Medicine, Fayoum University, Fayoum, EgyptSearch for more papers by this author First published: 26 July 2021 https://doi.org/10.1111/ijcp.14651 All authors have agreed to publish this paper in your journal and they confirm that this manuscript is not under publication in any journal. Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat Abstract Background Rheumatoid arthritis (RA) is an inflammatory autoimmune disease which affects various tissues and organs mainly joints. Serum microRNAs are considered a new class of non-coding RNA which plays a vital role in pathogenesis of RA. Methods The current study was conducted on 80 RA patients and 80 healthy participants. Serum expression levels of miR-224, miR-760, miR-483-5p, miR-378 and miR-375 were evaluated via real-time quantitative polymerase chain reaction (PCR). Results Significant upregulation of miR-224, miR-760, miR-483-5p, miR-378 and miR-375 was reported in the present study with respect to the control group (P = .031, P = .017, P = .026, P = .036 and P = .05, respectively). Furthermore, significant positive correlation between the abovementioned microRNAs with DAS28 score (P < .001, each) was demonstrated. Conclusion Early detection of RA could be achieved through evaluation of serum expression of miR-224, miR-760, miR-483-5p, miR-378 and miR-375 which also may be used as targets for treatment of patients with RA. Volume75, Issue11November 2021e14651 RelatedInformation
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