Produção Nacional
Revisado por pares
Biocompatibility of polyvinyl alcohol/trisodium trimetaphosphate as vitreous substitute in experimental vitrectomy model in rabbits
2021; Wiley; Volume: 110; Issue: 2 Linguagem: Inglês
10.1002/jbm.b.34923
ISSN1552-4981
AutoresRamon Antunes de Oliveira, Felipe Muralha, Alex Treiger Grupenmacher, Andreia de Araújo Morandim‐Giannetti, Patrícia Alessandra Bersanetti, Maurício Maia, Octaviano Magalhães,
Tópico(s)Corneal Surgery and Treatments
ResumoAbstract Synthetic hydrogels have been proposed as vitreous substitutes recently. This study aims to evaluate the biocompatibility of polyvinyl alcohol (PVA) crosslinked with trisodium trimetaphosphate (SMTP) hydrogel in rabbit vitrectomized eyes. Seven animals were submitted to pars plana vitrectomy and the vitreous was replaced by PVA/SMTP hydrogel. Optical coherence tomography, fluorescein angiogram, clinical, and electrophysiological (ERG) examinations were analyzed at baseline, on postoperative days 7 and 30. The fellow eye was used as the control group. Hydrogel opacification was observed and ERG recordings were reduced in the hydrogel group in rod response, b ‐wave cone response and flicker. A histological analysis showed retinal disorganization, presence of multinucleated cells, and intraretinal hydrogel particles. The PVA/SMTP hydrogel showed poor biocompatibility. Novel biomaterials compounds should be analyzed in vivo.
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