Voltar
Revisão Acesso aberto Produção Nacional Revisado por pares
BIBTEX RIS

Prognosis of Regenerative Endodontic Procedures in Mature Teeth: A Systematic Review and Meta-Analysis of Clinical and Radiographic Parameters

2021; Multidisciplinary Digital Publishing Institute; Volume: 14; Issue: 16 Linguagem: Inglês

10.3390/ma14164418

ISSN

1996-1944

Autores

Pantaleo Scelza, Fabiano Palmeira Gonçalves, Isleine Portal Caldas, Fernanda Nunes, Emanuelle Stellet Lourenço, Sandro Tavares, Marcela Baraúna Magno, Andréa Vaz Braga Pintor, Pietro Montemezzi, Emanuele Di Edoardo, Carlos Fernando de Almeida Barros Mourão, Gutemberg Gomes Alves, Míriam Zaccaro Scelza,

Tópico(s)

Dental Radiography and Imaging

Resumo

This work aimed to investigate the use of Regenerative Endodontic Procedures (REP) on the treatment of pulp necrosis in mature teeth through systematic review and meta-analysis of evidence on clinical and radiographic parameters before and after REP. A search was performed in different databases on 9 September 2020, including seven clinical studies and randomized controlled trials (RCT). The methodological quality was assessed using Revised Cochrane risk-of-bias (RoB 2) and Before-and-After tools. Meta-analyses were performed to evaluate the success incidences regarding the reduction of periapical lesion and recovery of sensitivity. The certainty of the evidence was assessed using GRADE. Meta-analysis showed a high overall success of 0.95 (0.92, 0.98) I2 = 6%, with high periapical lesion reduction at 12 months (0.93 (0.86, 0.96) I2 = 37%) and by the end of follow-up (0.91 (0.83, 0.96) I2 = 13%). Lower incidences of positive sensitivity response were identified for the electrical (0.58 (0.46, 0.70) I2 = 51%) and cold tests (0.70 (0.54, 0.84) I2 = 68%). The calculated levels of REP success were similar to those reported for immature teeth. With a very low certainty of evidence, the meta-analysis showed a high incidence of REP’s success for mature teeth with necrotic pulp evidenced by periapical lesion reduction and moderate positive responses to sensitivity tests.

Referência(s)