Produção Nacional
Smoking-Induced Oxidative Stress in Bone: The Effects on Bone Turnover
2021; Volume: 2; Issue: 2 Linguagem: Inglês
10.29245/2767-5130/2021/2.1138
ISSN2767-5130
AutoresJúlia Benini Kohler, Jader Joel Machado Junqueira, Taysa Cristiane Moreira da Silva, Marco Antônio Gonçalves Pontes Filho, I. de F. L. C. Tiberio, F.D.T.Q.S. Lopes, Alexandre Póvoa Barbosa,
Tópico(s)Bone Metabolism and Diseases
ResumoDespite of clinical evidence of increased incidence of bone diseases amongst smokers as well as worsening recovery in orthopedic surgeries, it is still unclear which pathological mechanisms are induced by smoking and how these events impair bone turnover. Animal models and in vitro studies have been used to better elucidate these questions and smoking-induced oxidative stress have been pointed as playing crucial role in the worsening of bone cells activities leading bone damage. Oxidative stress is a physiological mechanism characterized by an imbalance between oxidants and antioxidants components. This imbalance leads cell damage and consequent release of inflammatory mediators, resulting in structural changes that impair the functionality of compromised organ. In this review, we summarize findings from clinical, animal models and in vitro studies that have elucidated the importance of the oxidative stress induced by smoking in different bone cells activities, leading bone mineral and organic matrix structural changes.
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