Long COVID - the physical and mental health of children and non-hospitalised young people 3 months after SARS-CoV-2 infection; a national matched cohort study (The CLoCk) Study.
2021; Research Square (United States); Linguagem: Inglês
10.21203/rs.3.rs-798316/v1
AutoresTerence Stephenson, Terence Stephenson, Snehal M. Pinto Pereira, Roz Shafran, Bianca De Stavola, Natalia Rojas, Kelsey McOwat, Ruth Simmons, María Zavala, Lauren L. O’Mahoney, Trudie Chalder, Esther Crawley, Tamsin Ford, Anthony Harnden, Isobel Heyman, Olivia Swann, Liz Whittaker, CLoCk Consortium, Shamez Ladhani,
Tópico(s)COVID-19 and Mental Health
ResumoAbstract Introduction: We describe post-COVID symptomatology in a national sample of 11-17-year-old children and young people (CYP) with PCR-confirmed SARS-CoV-2 infection compared to test-negative controls. Methods and analysis: A cohort study of test-positive (n=3,065) and age-, sex- and geographically-matched test-negative CYP (n=3,739) completed detailed questionnaires 3 months post-test. Results : At PCR-testing, 35.4% of test-positives and 8.3% of test-negatives had any symptoms whilst 30.6% and 6.2%, respectively, had 3+ symptoms. At 3 months post-testing, 66.5% of test-positives and 53.3% of test-negatives had any symptoms, whilst 30.3% and 16.2%, respectively, had 3+ symptoms. Latent class analysis identified two classes, characterised by “few” or “multiple” symptoms. This latter class was more frequent among test-positives, females, older CYP and those with worse pre-test physical and mental health. Discussion: Test-positive CYP had a similar symptom profile to test-negative CYP but with higher prevalence of single and, particularly, multiple symptoms at PCR-testing and 3 months later.
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