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Multicatalytic Hybrid Materials for Biocatalytic and Chemoenzymatic Cascades—Strategies for Multicatalyst (Enzyme) Co-Immobilization

2021; Multidisciplinary Digital Publishing Institute; Volume: 11; Issue: 8 Linguagem: Inglês

10.3390/catal11080936

2073-4344

Aldo Araújo da Trindade Júnior, Yan Ferraz Ximenes Ladeira, Alexandre da Silva França, Rodrigo O. M. A. de Souza, Adolfo H. Moraes, Robert Wojcieszak, Ivaldo Itabaiana, Amanda Silva de Miranda,

Innovative Microfluidic and Catalytic Techniques Innovation

During recent decades, the use of enzymes or chemoenzymatic cascades for organic chemistry has gained much importance in fundamental and industrial research. Moreover, several enzymatic and chemoenzymatic reactions have also served in green and sustainable manufacturing processes especially in fine chemicals, pharmaceutical, and flavor/fragrance industries. Unfortunately, only a few processes have been applied at industrial scale because of the low stabilities of enzymes along with the problematic processes of their recovery and reuse. Immobilization and co-immobilization offer an ideal solution to these problems. This review gives an overview of all the pathways for enzyme immobilization and their use in integrated enzymatic and chemoenzymatic processes in cascade or in a one-pot concomitant execution. We place emphasis on the factors that must be considered to understand the process of immobilization. A better understanding of this fundamental process is an essential tool not only in the choice of the best route of immobilization but also in the understanding of their catalytic activity.