Portal de Periódicos da CAPES

Normalized protein catabolic rate and lymphopenia drive humoral response to the Pfizer BNT162b2 vaccine in haemodialysis patients

2021; Oxford University Press; Volume: 36; Issue: 11 Linguagem: Inglês

10.1093/ndt/gfab241

1460-2385

Amélie Jacq, Jean-Michel Rebibou, Emmanuelle Kohler, Charline Baudoin, Jean‐Baptiste Bour, Alexis de Rougemont, Elise Maréchal, Mathieu Legendre,

COVID-19 Impact on Reproduction

Coronavirus disease 2019 (COVID-19) is associated with high morbidity and mortality in patients on maintenance haemodialysis (HD) [1]. Thus dialysis patients were prioritized for anti-COVID vaccination [2]. However, the ideal vaccination schedule remains unknown in this population [3], as patients suffering from chronic kidney disease have an altered immune response [4], with a diminished vaccine response to the hepatitis B virus [5] and flu vaccines [6]. In this work we sought to evaluate the humoral response to the BNT162b2 anti-severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine and its associated factors in a French cohort of HD patients. In this monocentric observational study, 58 HD patients who received two doses of the BNT162b2 (Pfizer-BioNTech) vaccine were included. Vaccines were injected at the start of HD sessions, with 21 days between the first and second dose. Among the patients,...