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The Toxicology Investigators Consortium Case Registry—the 2021 Annual Report

2022; Springer Science+Business Media; Volume: 18; Issue: 4 Linguagem: Inglês

10.1007/s13181-022-00910-6

1937-6995

Jennifer S. Love, Dana L. Karshenas, Meghan B. Spyres, Lynn A. Farrugia, A. Min Kang, HoanVu Nguyen, Sharan Campleman, Shao Li, Paul M. Wax, Jeffery Brent, Kim Aldy, Michael G. Abesamis, Jennifer Acciani, Elizabeth Adeyeye, Alek Adkins, Peter Akpunonu, Hassan Al Balushi, Timothy E. Albertson, Adam Algren, Alexandra Amaducci, John Archer, Robert Avera, Kavita M. Babu, Keith Baker, Kevin Baumgartner, Noah Bearlin, Gillian A. Beauchamp, Vik Bebarta, David J. Betting, Michael C. Beuhler, Steven Bird, Matthew Blundell, William Boroughf, Kayla Bourgeois, Katherine Boyle, Evan Bradley, Wells Brambl, Nicklaus Brandehoff, Marielle Brenner, Daniel Brooks, Jennie Buchanan, Michele M. Burns, Alfred Cahana, Kevin Caja, Diane P. Calello, Vince Calleo, Alexa Camarena-Michel, Joshua Canning, Robert D. Cannon, Dazhe Cao, Jennifer Carey, Joseph Carpenter, Stephanie Carreiro, Jorge Andrés Ramos Castañeda, Rachel Castelli, Vincent Ceretto, Edward W. Cetaruk, James Chenoweth, Michael Christian, Richard Church, Joseph Clemons, Daniel Colby, Grant Thomas Comstock, Albert Conicella, Matthew D. Cook, Matt Correia, Robert A. Cox, Arthur Daigh, Paul I. Dargan, Klara De Baerdemaeker, Anthony DeGelorm, Jonathan de Olano, Jason M. Devgun, Christopher Dion, William H. Dribben, Anna Dean Dulaney, Bernard Eisenga, Lindsey Epperson, Rita Farah, Hank Farrar, Sing-Yi Feng, Derek J Fikse, E.M.R. Fisher, Jonathan Ford, Carolyn Fox, K.A. French, Blake Froberg, Jakub Furmaga, Michael Ganetsky, Ann-Jeannette Geib, Mellisa Gittinger, Kimberlie A. Graeme, Powell Graham, Kevin Greene, Spencer Greene, Stacey Hail, Laurie Seidel Halmo, Riley Hartmann, Benjamin W. Hatten, Kennon Heard, William Heise, Robert G. Hendrickson, Michelle A. Hieger, Ruby Hoang, Michael Hodgman, Jason Hoppe, B. Zane Horowitz, Cory M. Howard, Christopher Hoyte, Katherine M. Hurlbut, Adrienne Hughes, Laura Hunter, Janetta Iwanicki, Jeena Jacob, Laura P. James, Mohamed Jefri, Lilyanne Jewett, David Johnson, Seth G. Jones, Bryan Judge, Eric E. Kaczor, Sasha Kaiser, Louise Kao, Kenneth D. Katz, Ziad Kazzi, Mike Keenan, Emily Kiernan, Ronald I. Kirschner, Kurt Kleinschmidt, Nattakarn Kongkaew, Andrew L. Koons, Kathryn T. Kopec, Michael J. Kosnett, Anna Krasik, Melissa Kroll, Shana Kusin, Jeffrey Lai, Melisa W. Lai-Becker, Becky Latch, Ophir Lavon, Eric J. Lavonas, Michael P. Levine, Brian Lewis, Erica L. Liebelt, Natalie Linnemeyer, David T. Liss, Jean C.Y. Lo, Annette Lopez, David S. Loughran, Scott Lucyk, Yael Lurie, Nima Majlesi, Gregory Makar, Jade Malcho, Carin Malley, Michael B. Marlin, Stacy Marshall, Kelsey Martin, Nik Matsler, Charles McElyea, Christopher Meaden, Andrew A. Monte, Brent Morgan, Michael Mullins, Christine Murphy, Nicholas Nacca, K. Nanagas, Lewis S. Nelson, Natalie R. Neumann, Anh Duy Nguyen, Supa Niruntarai, Matthew J. Noble, Cherie Obilom, Aryn O’Connor, Katherine O’Donnell, Rittirak Othong, Daniel Ovakim, Daniel L. Overbeek, Kelly P. Owen, Pakhawadee Palungwachira, Mehruba Anwar Parris, Lesley Pepin, Todd Phillips, Chris Pitotti, Anthony F. Pizon, Lawrence S. Quang, John Michael Rague, Tony Rianprakaiasang, Shannon Rickner-Schmidt, Marc Rigatti, Morgan Riggan, Brad Riley, Daniel Rivera, Bryan R Ross, Brett Roth, Lindsay Schaack Rothstein, Michelle Ruha, Steven D. Salhanick, Ellen Salmo, Cynthia Santos, Matthew C. Scanlon, Jay L. Schauben, Pieter Scheerlinck, Evan S. Schwarz, Kartik R. Shah, Kerollos Shaker, Kapil Sharma, Sophia Sheikh, Joshua M. Shulman, M.D.C. Simpson, Jerry A. Snow, Dawn R. Sollee, Alaina Steck, Jennifer Stephani, Molly K. Stott, Ross Sullivan, Ryan Surmaitis, Courtney Temple, John Thompson, Michelle Thompson, Stephen L. Thornton, Lisa Thurgur, Michael Toce, Laura M. Tormoehlen, William J. Trautman, Chiemela Ubani, David Vearrier, George Wang, Sam C. Wang, George Warpinski, James T. Watson, M. Waters, Mary Wermuth, James D. Whitledge, Timothy J. Wiegand, Brian Wolk, David M. Wood, Mark Yarema, Luke Yip, Amy Young, Matthew Zuckerman,

Poisoning and overdose treatments

The Toxicology Investigators Consortium (ToxIC) Core Registry was established by the American College of Medical Toxicology in 2010. The Core Registry collects data from participating sites with the agreement that all bedside and telehealth medical toxicology consultations will be entered. This twelfth annual report summarizes the registry's 2021 data and activity with its additional 8552 cases. Cases were identified for inclusion in this report by a query of the ToxIC database for any case entered from January 1 to December 31, 2021. Detailed data was collected from these cases and aggregated to provide information, which included demographics, reason for medical toxicology evaluation, agent and agent class, clinical signs and symptoms, treatments and antidotes administered, mortality, and whether life support was withdrawn. Gender distribution included 50.4% of cases in females, 48.2% of cases in males, and 1.4% of cases in transgender or gender non-conforming individuals. Non-opioid analgesics were the most commonly reported agent class (14.9%), followed by opioids (13.1%). Acetaminophen was the most common agent reported. Fentanyl was the most common opioid reported and was responsible for the greatest number of fatalities. There were 120 fatalities, comprising 1.4% of all cases. Major trends in demographics and exposure characteristics remained similar to past years' reports. Sub-analyses were conducted to describe new demographic characteristics, including marital status, housing status and military service, the continued COVID-19 pandemic and related toxicologic exposures, and novel substances of exposure.