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Construction of 2-alkynyl aza-spiro[4,5]indole scaffolds via sequential C–H activations for modular click chemistry libraries

2021; Royal Society of Chemistry; Volume: 57; Issue: 69 Linguagem: Inglês

10.1039/d1cc02798k

1364-548X

Jun Zhang, Mengmeng Wang, Huiying Wang, Hui Xu, Junjie Chen, Ziqiong Guo, Biao Ma, Shurong Ban, Hui‐Xiong Dai,

Synthesis and Catalytic Reactions

Herein, we have developed a strategy of sequential C–H activations of indole to construct novel 2-alkynyl aza-spiro[4,5]indole scaffolds, which incorporated both alkyne and spiro-units into indole.