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Prevalence and risk factors for antimicrobial resistance among newborns with gram-negative sepsis

2021; Public Library of Science; Volume: 16; Issue: 8 Linguagem: Inglês

10.1371/journal.pone.0255410

1932-6203

Semaria Solomon, Oluwasefunmi Akeju, Oludare A. Odumade, Rozina Ambachew, Gebreyohannes Zenebe, Kimiko Van Wickle, Mahlet Abayneh, Gesit Metaferia, Maria J. Carvalho, Kathryn Thomson, Kirsty Sands, Timothy R. Walsh, Rebecca Milton, Frederick G. B. Goddard, Delayehu Bekele, Grace J. Chan,

Antibiotic Use and Resistance

Newborn sepsis accounts for more than a third of neonatal deaths globally and one in five neonatal deaths in Ethiopia. The first-line treatment recommended by WHO is the combination of gentamicin with ampicillin or benzylpenicillin. Gram-negative bacteria (GNB) are increasingly resistant to previously effective antibiotics.