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Effects of antibiotic resistance, drug target attainment, bacterial pathogenicity and virulence, and antibiotic access and affordability on outcomes in neonatal sepsis: an international microbiology and drug evaluation prospective substudy (BARNARDS)

2021; Elsevier BV; Volume: 21; Issue: 12 Linguagem: Inglês

10.1016/s1473-3099(21)00050-5

1474-4457

Kathryn Thomson, Calie Dyer, Feiyan Liu, Kirsty Sands, Edward Portal, Maria J. Carvalho, M. Barrell, Ian Boostrom, Susanna Dunachie, Refath Farzana, Ana Ferreira, Francis Frayne, Brekhna Hassan, Ellis L. Jones, Lim Jones, Jordan Mathias, Rebecca Milton, Jessica Rees, Grace J. Chan, Delayehu Bekele, Mahlet Abayneh, Sulagna Basu, Ranjan K. Nandy, Bijan Saha, Kenneth Iregbu, Fatima Modibbo, Stella Uwaezuoke, Rabaab Zahra, Haider Shirazi, Najeeb U Syed, Jean-Baptiste Mazarati, Aniceth Rucogoza, Lucie Gaju, Shaheen Mehtar, Andre Nyandwe Hamama Bulabula, Andrew Whitelaw, J. G. Coen van Hasselt, Timothy R. Walsh, Samir K. Saha, Mohammad Shahidul Islam, Zabed Bin-Ahmed, Wazir Ahmed, Taslima Begum, Mitu Chowdhury, Shaila Sharmin, Chumki Rani Dey, Uttam, Mohammad Abdul Matin, Sowmitra Ranjan Chakraborty, Sadia Tasmin, Dipa Rema, Rashida Khatun, Liza Nath, Nigatu Balkachew, Delayehu Bekele, Katherine Cl Schaughency, Semaria Solomon, Zenebe Gebreyohanes, Rozina Ambachew, Oludare A. Odumade, Misgana Haileselassie, Grace J. Chan, Abigail A. Russo, Redeat Workneh, Gesit Metaferia, Mahlet Abayneh, Yahya Mohammed, Tefera Biteye, Alula M. Teklu, Wendimagegn Gezahegn, Partha Sarathi Chakravorty, Anuradha Mukherjee, Ranjan K. Nandy, Samarpan Roy, Anuradha Sinha, Sharmi Naha, Sukla Saha Malakar, Siddhartha Bose, Monaki Majhi, Subhasree Sahoo, Putul Mukherjee, Sumitra Kumari Routa, Chaitali Nandi, Sulagna Basu, Bijan Saha, Pinaki Chattopadhyay, Fatima Z Modibbo, Stella Uwaezuoke, Dilichukwu Meduekwe, Khairiyya Muhammad, Queen Nsude, Ifeoma Ukeh, Mary-Joe Okenu, Chinenye Akpulu, Samuel Yakubu, Vivian Asunugwo, Folake Aina, Isibong Issy, Dolapo Adekeye, Adiele Eunice, Abdulmlik Amina, R Oyewole, I Oloton, BC Nnaji, M Umejiego, PN Anoke, Saheed O. Adebayo, GO Abegunrin, OB Omotosho, Risqot Garba Ibrahim, Blessing Njideka Igwe, M Abroko, K Balami, L Bayem, C H Anyanwu, Hidenori Haruna, J Okike, K Goroh, M Boi-Sunday, Augusta Ugafor, Maryam Makama, Kaniba Ndukwe, Anastesia Odama, Hadiza Yusuf, Patience Wachukwu, Kachalla Yahaya, Titus Kalade Colsons, Mercy Kura, Damilola Orebiyi, Kenneth Iregbu, Chukwuemeka Mmadueke, Lamidi Isah Audu, Nura Idris, Safiya Gambo, Jamila Ibrahim, Edwin Precious, Ashiru Hassan, Shamsudden Gwadabe, Adeola Adeleye Falola, Muhammad Aliyu, Amina Ibrahim, Aisha Mukaddas, Rashida Yakubu Khalid, Fatima Ibrahim Alkali, Maryam Yahaya Muhammad, Fatima Mohammad Tukur, Surayya Mustapha Muhammad, Adeola Shittu, Murjanatu Bello, Muhammad Abubakar Hassan, Fatima Habib Sa ad, Aishatu Kassim, Haider Shirazi, Adil Muhammad, Rabaab Zahra, Syed Najeeb Ullah, Muhammad Hilal Jan, Rubina Kamran, Sajana, Jazba Saeed, Noreen Maqsood, M. Zafar, Saraeen Sadiq, Sumble Ahsan, Madiha Tariq, Sidra Sajid, Hasma Mustafa, Anees-ur Rehman, Atif Muhammad, Gahssan Mehmood, Mahnoor Nisar, Shermeen Akif, Tahira Yasmeen, Sabir Nawaz, Anam Shanal Atta, Mian Laiq-ur-Rehman, Robina Kousar, Kalsoom Bibi, Kosar Waheed, Zainab Majeed, Ayesha Jalil, Espoir Kajibwami, Aniceth Rucogoza, Innocent Nzabahimana, Jean-Baptiste Mazarati, Lucie Gaju, Kankundiye Riziki, Brigette Uwamahoro, Rachel Uwera, Eugenie Nyiratuza, Muzungu Kumwami, Violette Uwitonze, Marie C Horanimpundu, Francine Nzeyimana, Prince Mitima, Angela Dramowski, Andrew Whitelaw, Lauren Paterson, Mary Frans, Marvina Johnson, Eveline Swanepoel, Zoleka Bojana, Mieme du Preez, Shaheen Mehtar, Andre Nyandwe Hamama Bulabula, Feiyan Liu, Johan GC van Hasselt, Timothy R. Walsh, Kirsty Sands, Maria J. Carvalho, Rebecca Milton, Kathryn Thomson, Edward Portal, Jordan Mathias, Calie Dyer, Ana Ferreira, Robert Andrews, John E. Watkins, David Gillespie, Kerenza Hood, Katie Taiyai, Nigel Kirby, Maria Nieto, Thomas Hender, Patrick G. Hogan, Habiba Saif, Brekhna Hassan, Ellis L. Jones, M. Barrell, Ian Boostrom, Francis Frayne, Jessica Rees, Lim Jones, Susanna Dunachie, B Spiller, Julian Parkhill,

Pneumonia and Respiratory Infections

Sepsis is a major contributor to neonatal mortality, particularly in low-income and middle-income countries (LMICs). WHO advocates ampicillin-gentamicin as first-line therapy for the management of neonatal sepsis. In the BARNARDS observational cohort study of neonatal sepsis and antimicrobial resistance in LMICs, common sepsis pathogens were characterised via whole genome sequencing (WGS) and antimicrobial resistance profiles. In this substudy of BARNARDS, we aimed to assess the use and efficacy of empirical antibiotic therapies commonly used in LMICs for neonatal sepsis.