Sustained Elevated Blood Pressure Accelerates Atherosclerosis Development in a Preclinical Model of Disease
2021; Multidisciplinary Digital Publishing Institute; Volume: 22; Issue: 16 Linguagem: Inglês
10.3390/ijms22168448
ISSN1661-6596
AutoresAndrés González-Guerra, Marta Roche-Molina, Nieves García-Quintáns, Cristina Sánchez‐Ramos, Daniel Martín-Pérez, Mariya Lytvyn, Javier de Nicolás‐Hernández, José Rivera, Diego F. Arroyo, David Sanz‐Rosa, Juan A. Bernal,
Tópico(s)Cardiovascular Health and Disease Prevention
ResumoThe continuous relationship between blood pressure (BP) and cardiovascular events makes the distinction between elevated BP and hypertension based on arbitrary cut-off values for BP. Even mild BP elevations manifesting as high-normal BP have been associated with cardiovascular risk. We hypothesize that persistent elevated BP increases atherosclerotic plaque development. To evaluate this causal link, we developed a new mouse model of elevated BP based on adeno-associated virus (AAV) gene transfer. We constructed AAV vectors to support transfer of the
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