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Reperfusion therapy for acute ischemic stroke in older people: An observational real‐life study

2021; Wiley; Volume: 69; Issue: 11 Linguagem: Inglês

10.1111/jgs.17394

1532-5415

Justine Sudre, Laura Venditti, Claire Ancelet, Olivier Chassin, Mariana Sarov, Didier Smadja, Nicolas Chausson, François Lun, Olga Lainé, Emmanuelle Duron, Christiane Verny, Laurent Spelle, Alexandra Rouquette, Nicolas Legris, Christian Denier,

Venous Thromboembolism Diagnosis and Management

Abstract Background While randomized clinical trials have shown the benefit of thrombolysis and endovascular thrombectomy (EVT) in patients with acute ischemic stroke (AIS), we aimed to describe in a real‐life study the differences between older (>80 years old) and younger patients treated for AIS. Methods Thousand patients treated with thrombolysis and/or EVT were consecutively included in a prospective monocentric database (admitted from December 2015 to May 2019 in our comprehensive stroke center). Demographic data with detailed history, baseline physical examinations and treatments, laboratory and imaging data, prestroke functional status, and outcome 3 months after stroke were analyzed. Results Older patients ( n = 357) had more baseline comorbidities and lower levels of prestroke independence (modified Rankin scale ≤2; 67.2% vs. 96.1%) and more severe strokes (median National Institute of Health Stroke Score [NIHSS] 15 vs. 12; p < 0.001) than younger patients ( n = 643). There was no difference in the reperfusion treatments used or treatment timelines. In older patients, good functional status at 3 months was less common (29.7% vs. 61.3%) and mortality was higher (37.1% vs. 11.4%) than in younger patients. Younger age was independently associated with better prognosis (odds ratio [OR] 0.37, 95% confidence interval [CI]: 0.20–0.67; p = 0.001) and lower mortality (OR 4.38, 95% CI: 2.11–9.09; p < 0.001). Among older adults, features associated with good outcome at 3 months were age (OR 0.89, 95% CI: 0.81–0.97; p = 0.01), initial NIHSS (OR 0.89, 95% CI: 0.83–0.94; p < 0.0001), and absence of severe leukoaraiosis, anticoagulant treatment, and symptomatic intracerebral hemorrhage following reperfusion therapy (respectively, OR 0.42, 95% CI: 0.19–0.93; p = 0.03; OR = 0.07, 95% CI: 0.01–0.70; p = 0.02; and OR = 0.07, 95% CI: 0.01–0.61; p = 0.02). Conclusion Although reperfusion therapy was less successful in older patients, these patients may benefit from acute recanalization despite their age. With an increasing older adult population, high‐quality prospective studies are still required to better predict functional outcome and clarify the criteria that would allow better selection of appropriate treatment.