Artigo Revisado por pares

Exploring the effect of Mg2+ substitution on amorphous calcium phosphate nanoparticles

2021; Elsevier BV; Volume: 606; Linguagem: Inglês

10.1016/j.jcis.2021.08.033

ISSN

1095-7103

Autores

Rita Gelli, Lorenzo Briccolani-Bandini, Marco Pagliai, Gianni Cardini, Francesca Ridi, Piero Baglioni,

Tópico(s)

Polymer Surface Interaction Studies

Resumo

The study of Amorphous Calcium Phosphate (ACP) has become a hot topic due to its relevance in living organisms and as a material for biomedical applications. The preparation and characterization of Mg-substituted ACP nanoparticles (AMCP) with tunable Ca/Mg ratio is reported in the present study to address the effect of Mg2+ on their structure and stability.AMCPs particles were synthesized by precipitation of the precursors from aqueous solutions. The particles were analyzed in terms of morphology, crystallinity, and thermal stability, to get a complete overview of their physico-chemical characteristics. Computational methods were also employed to simulate the structure of ACP clusters at different levels of Mg2+ substitution.Our results demonstrate that AMCP particles with tunable composition and crystallinity can be obtained. The analysis of the heat-induced crystallization of AMCP shows that particles' stability depends on the degree of Mg2+ substitution in the cluster, as confirmed by computational analyses. The presented results shed light on the effect of Mg2+ on ACP features at different structural levels and may be useful guidelines for the preparation and design of AMCP particles with a specific Ca/Mg ratio.

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