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COVID-19 vaccines: addressing hesitancy in young people with allergies

2021; Elsevier BV; Volume: 9; Issue: 10 Linguagem: Inglês

10.1016/s2213-2600(21)00370-2

2213-2619

Elissa M. Abrams, Marcus Shaker, Ian Sinha, Matthew Greenhawt,

Respiratory viral infections research

According to the COVID-19 dashboard by Johns Hopkins University, as of July 30, 2021, there have been 196 910 814 cases of COVID-19, with more than 4·1 million deaths globally. Rollout of several COVID-19 vaccines provided hope towards mitigating disease burden, and, thus far, more than 3·9 billion vaccine doses have been administered around the world. Any return to normalcy relies on high vaccine uptake. As noted by a recent piece in The New England Journal of Medicine, "we look to vaccines to give us back our world".1Klass P Ratner AJ Vaccinating children against Covid-19—the lessons of measles.N Engl J Med. 2021; 384: 589-591Crossref PubMed Scopus (52) Google Scholar On May 10, 2021, the US Food and Drug Administration expanded its emergency use authorisation for the Pfizer-BioNtech mRNA COVID-19 vaccine (BNT162b2) in adolescents aged 12–15 years.2Centers for Disease Control and PreventionAcceptability of adolescent COVID-19 vaccination among adolescents and parents of adolescents—United States, April 15–23, 2021.https://www.cdc.gov/mmwr/volumes/70/wr/mm7028e1.htm?s_cid=mm7028e1_wDate: July 9, 2021Date accessed: August 4, 2021Google Scholar This approval now demands increasing focus on achieving high immunisation rates within adolescent populations. Immunisation within these populations has the dual direct benefit of protecting children and adolescents against disease morbidity and mortality, and reducing spread among the clinically vulnerable.1Klass P Ratner AJ Vaccinating children against Covid-19—the lessons of measles.N Engl J Med. 2021; 384: 589-591Crossref PubMed Scopus (52) Google Scholar Despite evidence that COVID-19 vaccines are both safe and effective, there is increasing evidence of COVID-19 vaccine hesitancy among children and adolescents and their families.2Centers for Disease Control and PreventionAcceptability of adolescent COVID-19 vaccination among adolescents and parents of adolescents—United States, April 15–23, 2021.https://www.cdc.gov/mmwr/volumes/70/wr/mm7028e1.htm?s_cid=mm7028e1_wDate: July 9, 2021Date accessed: August 4, 2021Google Scholar A survey, done in the USA between April 15 and April 23, 2021, by the Centers for Disease Control and Prevention (CDC), found that only 55·5% of 1022 parents and guardians of unvaccinated adolescents aged 12–17 years would "definitely" or "probably" allow their child to receive a COVID-19 vaccine, and only 51·7% of 985 adolescents aged 13–17 years would "definitely" or "probably" receive a COVID-19 vaccine.2Centers for Disease Control and PreventionAcceptability of adolescent COVID-19 vaccination among adolescents and parents of adolescents—United States, April 15–23, 2021.https://www.cdc.gov/mmwr/volumes/70/wr/mm7028e1.htm?s_cid=mm7028e1_wDate: July 9, 2021Date accessed: August 4, 2021Google Scholar Among parents who expressed hesitancy, a commonly reported factor that would increase the likelihood of COVID-19 vaccine acceptance was more information about safety. In fact, for families of individuals with allergies, including those with asthma, one of the major concerns is fear of an allergic reaction to the vaccine.3Glover RE Urquhart R Lukawska J Blumenthal KG Vaccinating against covid-19 in people who report allergies.BMJ. 2021; 372: n120Crossref PubMed Scopus (24) Google Scholar, 4Greenhawt M Abrams EM Shaker M et al.The risk of allergic reaction to SARS-CoV-2 vaccines and recommended evaluation and management: a systematic review, meta-analysis, GRADE assessment, and international consensus approach.J Allergy Clin Immunol Pract. 2021; (published online June 18.)https://doi.org/10.1016/j.jaip.2021.06.006Summary Full Text Full Text PDF Scopus (157) Google Scholar This concern is easy to address. It must be emphasised to children and adolescents and their families, including to those with allergic conditions such as asthma, that the risk of having an anaphylactic reaction to a COVID-19 vaccine is exceptionally rare. A systematic review and meta-analysis noted that the incidence of an allergic reaction to an mRNA-based COVID-19 vaccine is 7·91 cases per million doses (95% CI 4·02–15·59).4Greenhawt M Abrams EM Shaker M et al.The risk of allergic reaction to SARS-CoV-2 vaccines and recommended evaluation and management: a systematic review, meta-analysis, GRADE assessment, and international consensus approach.J Allergy Clin Immunol Pract. 2021; (published online June 18.)https://doi.org/10.1016/j.jaip.2021.06.006Summary Full Text Full Text PDF Scopus (157) Google Scholar In a prospective study of health-care employees in Boston, MA, USA, COVID-19 mRNA vaccine anaphylaxis was confirmed in only 16 (0·025%, 95% CI 0·014–0·040) of 64 900 employees, who all completely recovered without any episodes of shock or intubation.5Blumenthal KG Robinson LB Camargo Jr, CAJ et al.Acute allergic reactions to mRNA COVID-19 vaccines.JAMA. 2021; 325: 1562-1565Crossref PubMed Scopus (179) Google Scholar No fatalities from COVID-19 vaccine-related anaphylaxis have been reported to date, the allergic reactions resolve rapidly without long-term sequelae,4Greenhawt M Abrams EM Shaker M et al.The risk of allergic reaction to SARS-CoV-2 vaccines and recommended evaluation and management: a systematic review, meta-analysis, GRADE assessment, and international consensus approach.J Allergy Clin Immunol Pract. 2021; (published online June 18.)https://doi.org/10.1016/j.jaip.2021.06.006Summary Full Text Full Text PDF Scopus (157) Google Scholar and revaccination after an initial reaction is well tolerated.6Krantz MS Kwah JH Stone Jr, CA et al.Safety evaluation of the second dose of messenger RNA COVID-19 vaccines in patients with immediate reactions to the first dose.JAMA Intern Med. 2021; (published online July 26.)https://doi.org/10.1001/jamainternmed.2021.3779Crossref PubMed Scopus (77) Google Scholar Clinicians must reiterate such messaging to families to mitigate vaccine hesitancy due to concerns over anaphylaxis. Misinformation regarding vaccine safety (allergic or other related events) is rampant. The CDC survey on vaccine hesitancy found that federal, state, and local health officials and primary care health-care workers were the most trusted sources of COVID-19 vaccine information among families.2Centers for Disease Control and PreventionAcceptability of adolescent COVID-19 vaccination among adolescents and parents of adolescents—United States, April 15–23, 2021.https://www.cdc.gov/mmwr/volumes/70/wr/mm7028e1.htm?s_cid=mm7028e1_wDate: July 9, 2021Date accessed: August 4, 2021Google Scholar Clinicians have an essential role in discussing how and where families obtain information, in providing accurate information in the clinical encounter, and, when indicated, in directing people to reliable sources of online information.7Abrams EM Greenhawt M Mitigating misinformation and changing the social narrative.J Allergy Clin Immunol Pract. 2020; 8: 3261-3263Summary Full Text Full Text PDF PubMed Scopus (10) Google Scholar As noted by the CDC, "efforts focusing on clearly communicating to the public the benefits and safety of COVID-19 vaccination for adolescents, particularly by health care professionals, could help increase confidence in adolescent COVID-19 vaccine and vaccination coverage".2Centers for Disease Control and PreventionAcceptability of adolescent COVID-19 vaccination among adolescents and parents of adolescents—United States, April 15–23, 2021.https://www.cdc.gov/mmwr/volumes/70/wr/mm7028e1.htm?s_cid=mm7028e1_wDate: July 9, 2021Date accessed: August 4, 2021Google Scholar Certain groups of children and their families have expressed higher vaccine hesitancy rates; these groups are more likely to face other adverse social determinants of health.2Centers for Disease Control and PreventionAcceptability of adolescent COVID-19 vaccination among adolescents and parents of adolescents—United States, April 15–23, 2021.https://www.cdc.gov/mmwr/volumes/70/wr/mm7028e1.htm?s_cid=mm7028e1_wDate: July 9, 2021Date accessed: August 4, 2021Google Scholar The CDC survey found that there were significantly fewer parents reporting intent for their adolescent to receive a COVID-19 vaccine among respondents identifying as Hispanic or who had less than a bachelor's degree.2Centers for Disease Control and PreventionAcceptability of adolescent COVID-19 vaccination among adolescents and parents of adolescents—United States, April 15–23, 2021.https://www.cdc.gov/mmwr/volumes/70/wr/mm7028e1.htm?s_cid=mm7028e1_wDate: July 9, 2021Date accessed: August 4, 2021Google Scholar Similarly, other studies have found higher rates of vaccine hesitancy in minority ethnic populations.3Glover RE Urquhart R Lukawska J Blumenthal KG Vaccinating against covid-19 in people who report allergies.BMJ. 2021; 372: n120Crossref PubMed Scopus (24) Google Scholar Those facing adverse social determinants, including lower health literacy, and minority ethnic populations have been disproportionately impacted by COVID-19 morbidity and mortality.8Abrams EM Szefler SJ COVID-19 and the impact of social determinants of health.Lancet Respir Med. 2020; 8: 659-661Summary Full Text Full Text PDF PubMed Scopus (470) Google Scholar Social determinants of health must be prioritised as part of pandemic research and policy implementation.8Abrams EM Szefler SJ COVID-19 and the impact of social determinants of health.Lancet Respir Med. 2020; 8: 659-661Summary Full Text Full Text PDF PubMed Scopus (470) Google Scholar In addition, efforts to reduce vaccine hesitancy should focus on such groups. Clinicians must approach vaccine hesitancy with respect and empathy regarding the pre-eminent fears on the minds of children and their families. Best practices to address COVID-19 vaccine hesitancy should build off past successful approaches to vaccine hesitancy. For example, through motivational interviewing techniques, clinicians can establish connection, demonstrate respect, support the autonomy of children and families, and create a space where meaningful conversations can occur.9Gabarda A Butterworth SW Using best practices to address COVID-19 vaccine hesitancy: the case for the motivational interviewing approach.Health Promot Pract. 2021; (published online May 8.)https://doi.org/10.1177/15248399211016463Crossref PubMed Scopus (35) Google Scholar Understanding the family's readiness to receive new information and exploring where families experience uncertainty in their decision making creates opportunities for information exchange that can change health behaviour. Such an approach can help families to better understand the true risks and benefits of vaccination and "evoke a person's own argument for vaccination to decrease vaccine hesitancy".9Gabarda A Butterworth SW Using best practices to address COVID-19 vaccine hesitancy: the case for the motivational interviewing approach.Health Promot Pract. 2021; (published online May 8.)https://doi.org/10.1177/15248399211016463Crossref PubMed Scopus (35) Google Scholar Moving forward, conveying the message that COVID-19 vaccines are safe and effective, and that potentially serious complications, such as allergic reactions, are very rare (and occur with minimal morbidity), might help to mitigate misinformation and alleviate concerns among children, adolescents, and their families, and particularly those with allergic conditions. Keeping an open mind by inviting and hearing the lived experience of children and families can help to facilitate conversations in which families can be provided with the information they need to help them make informed decisions. Change can happen slowly, but always begins with a first step. EMA is an employee of the Public Health Agency of Canada, but the views expressed in this Comment are her own and not those of the Public Health Agency of Canada. MS is a member of the Joint Taskforce on Allergy Practice Parameters; has a family member who is the chief executive officer of Altrix Medical; and serves on the editorial boards of the Journal of Food Allergy and the Annals of Allergy, Asthma & Immunology. IS declares no competing interests. MG is an expert panel and coordinating committee member of Guidelines for Peanut Allergy Prevention sponsored by the National Institute of Allergy and Infectious Diseases; has served as a consultant for the Canadian Transportation Agency, Thermo Fisher, Intrommune, and Aimmune Therapeutics; is a member of physician or medical advisory boards for Aimmune Therapeutics, DBV Technologies, Sanofi/Genzyme, GlaxoSmithKline, Genentech, Nutricia, Pfizer, Novartis, Kaléo Pharmaceutical, Nestlé, US WorldMeds, Aquestive, Allergy Therapeutics, Allergenis, Aravax, Prota, and Monsanto; is a member of the scientific advisory council for the National Peanut Board; has received honorarium for lectures from Thermo Fisher, Aimmune Therapeutics, DBV Technologies, Before Brands, multiple state allergy societies, the American College of Allergy Asthma and Immunology, and the European Academy of Allergy and Clinical Immunology; is an associate editor for the Annals of Allergy, Asthma & Immunology; and is a member of the Joint Taskforce on Allergy Practice Parameters.