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Recent advances in biosensing approaches for point-of-care breast cancer diagnostics: challenges and future prospects

2021; Royal Society of Chemistry; Volume: 3; Issue: 19 Linguagem: Inglês

10.1039/d1na00453k

2516-0230

Anju Joshi, Anil Vishnu G. K., Tushar Sakorikar, Arif Mohd. Kamal, Jayant S. Vaidya, Hardik J. Pandya,

Biosensors and Analytical Detection

Timely and accurate diagnosis of breast cancer is essential for efficient treatment and the best possible survival rates. Biosensors have emerged as a smart diagnostic platform for the detection of biomarkers specific to the onset, recurrence, and therapeutic drug monitoring of breast cancer. There have been exciting recent developments, including significant improvements in the validation, sensitivity, specificity, and integration of sample processing steps to develop point-of-care (POC) integrated micro-total analysis systems for clinical settings. The present review highlights various biosensing modalities (electrical, optical, piezoelectric, mass, and acoustic sensing). It provides deep insights into their design principles, signal amplification strategies, and comparative performance analysis. Finally, this review emphasizes the status of existing integrated micro-total analysis systems (μ-TAS) for personalized breast cancer therapeutics and associated challenges and outlines the approach required to realize their successful translation into clinical settings.