Clonal Hematopoiesis: From Mechanisms to Clinical Intervention
2021; American Association for Cancer Research; Volume: 11; Issue: 12 Linguagem: Inglês
10.1158/2159-8290.cd-21-0901
ISSN2159-8290
AutoresThomas Köhnke, Ravindra Majeti,
Tópico(s)Hematopoietic Stem Cell Transplantation
ResumoOur knowledge of how clonal hematopoiesis relates to diverse health conditions has grown vastly over the past years, touching upon many specialties beyond cancer medicine. Given that clonal hematopoiesis can act as a precursor to overt disease in many settings, the promise of early intervention has garnered much attention. In this review, we discuss the state of clonal hematopoiesis research and outline the challenges in developing clinical trials of early interventions. We anticipate that incidental findings of clonal hematopoiesis will become more common in the near future, but evidence-based efforts of how to manage these findings is currently lacking.
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