Produção Nacional
Revisado por pares
Xyloglucan and Concanavalin A based dressings in the topical treatment of mice wound healing process
2021; Elsevier BV; Volume: 2; Linguagem: Inglês
10.1016/j.carpta.2021.100136
ISSN2666-8939
AutoresIsabel Renata de Souza Arruda, Marthyna Pessoa de Souza, Paulo Rodinei Soares Lopes, Priscilla Barbosa Sales de Albuquerque, Túlio D. Silva, Paloma Lys de Medeiros, Márcia Vanusa da Silva, Maria Tereza dos Santos Correia, A. A. Vicente, Maria G. Carneiro‐da‐Cunha,
Tópico(s)Silk-based biomaterials and applications
ResumoFor medical biomaterials, xyloglucan dispersions can form films or gels to be applied as a wound dressing. For this purpose, the structural characterization of xyloglucan dressing (XG) and xyloglucan dressing containing 0.5 mg/mL of concanavalin A (XGL) was performed. The lectin release capacity and stability, cytotoxicity, and pro-wound healing effects were also investigated. XG and XGL films were prepared by mixing 0.5 % (w/v) xyloglucan with 0.3 % (v/v) glycerol. The ConA incorporated in the xyloglucan dressing maintained its biological activity for fourteen days in a controlled-release manner. The films were non-toxic, homogeneous, flexible, and accelerated the wound contraction compared with the control group, promoting less infiltration of inflammatory cells, angiogenesis, remodeling, and early epithelization. The films also alleviate the inflammation phase by reducing the production of pro-inflammatory cytokines (IFN-γ, TNF-α, IL-1β, IL-6, and IL-12), especially the XGL film, which promoted the up- and down-regulation of important proteins associated with the wound repair. All these findings suggest that XG and XGL films may represent a good therapeutic approach for wound healing applications.
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