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Family History of Thyroid Disease and Risk of Congenital Hypothyroidism in Neonates with Down Syndrome in Iraq

2021; RELX Group (Netherlands); Linguagem: Inglês

10.2139/ssrn.3907915

1556-5068

Hany A. Alhasany, Mohammed AH Jabarah AL-Zobaidy, Ali A. Albu-Rghaif, Hany Akeel Al-Hussaniy,

Congenital Diaphragmatic Hernia Studies

Introduction: Family history of thyroid disease (FHTD) as risk factor for congenital hypothyroidism (CH) in patients with Down syndrome (DS) has not yet been explored.Objective: To determine whether FHTD is associated with an increased risk for CH in DS.Method: 220 newborns with DS were studied in a case-control study. Thyroid function tests were compared between 37 neonates with DS with FHTD (cases) and 183 DS newborns without FHTD (reference group). Multivariate logistic regression analysis was used to examine the data, and adjusted odds ratios (aORs) with respective 95 percent confidence intervals (CIs) were produced.Results: Nine newborns with DS in our sample had CH (4.1%). FHTD showed an association with CH in neonates with DS (aOR = 8.3, 95% CI: 2.0-34.3), particularly in males (aOR = 9.0, 95% CI: 1.6-49.6). In contrast, newborns with DS without FHTD were less likely to suffer from CH (aOR = 0.4, 95% CI: 0.1-0.8).Conclusions: FHTD thorough evaluation can be a simple and accessible technique for identifying newborns with DS who are more likely to develop CH.Funding Information: The authors were not sponsored to carry out this article.Declaration of Interests: The authors declare that they have no conflict of interest.Ethics Approval Statement: The study was approved by the Ethics Committee in – Baghdad- Iraq. The authors have obtained the informed consent of the patients and / or subjects referred to in the article.