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The NHLBI Study on Long-terM OUtcomes after the Multisystem Inflammatory Syndrome In Children (MUSIC): Design and Objectives

2021; Elsevier BV; Volume: 243; Linguagem: Inglês

10.1016/j.ahj.2021.08.003

1097-6744

Dongngan T. Truong, Felicia Trachtenberg, Gail D. Pearson, Audrey Dionne, Matthew D. Elias, Kevin G. Friedman, Kerri Hayes, Lynn Mahony, Brian W. McCrindle, Matthew E. Oster, Victoria L. Pemberton, Andrew J. Powell, Mark W. Russell, Lara S. Shekerdemian, Mary Beth F. Son, Michael D. Taylor, Jane W. Newburger, Audrey Dionne, Matthew D. Elias, Therese M. Giglia, Kimberly E. McHugh, Andrew M. Atz, Scott Pletzer, Dongngan T. Truong, Mark W. Russell, Sean M. Lang, R. Mark Payne, Jyoti K. Patel, Matthew E. Oster, Lara S. Shekerdemian, Ricardo Pignatelli, Kristen Sexson, Brian W. McCrindle, Christopher Wai Kei Lam, Andréea Dragulescu, Rae SM Young, Beth Gamulka, Anita Krishnan, Brett R. Anderson, Kanwal M. Farooqi, Divya Shakti, Aimee S. Parnell, Onyekachukwu Osakwe, Michelle Sykes, Lerraughn M. Morgan, Carl Y. Owada, Daniel Forsha, Michael R. Carr, Kae Watanabe, Michael A. Portman, Kristen B. Dummer, Jane C. Burns, Adriana H. Tremoulet, Kavita Sharma, Pei‐Ni Jone, Michelle Hite Heather Heizer, Keren Hasbani, Shubhika Srivastava, Elizabeth Mitchell, Camden L. Hebson, Jacqueline Szmuszkovicz, Pierre C. Wong, Andrew L. Cheng, Jodie K. Votava‐Smith, Shuo Wang, Sindhu Mohandas, Gautam K. Singh, Sanjeev Aggarwal, Yamuna Sanil, Tamara T. Bradford, Juan Carlos Muniz, Jennifer S. Li, Michael J. Campbell, Stephanie S. Handler, J. Ryan Shea, Timothy M. Hoffman, Wayne Franklin, Arash Sabati, Todd Nowlen, Maryanne Chrisant,

Coronary Artery Anomalies

The Long-terM OUtcomes after the Multisystem Inflammatory Syndrome In Children (MUSIC) study aims to characterize the frequency and time course of acute and long-term cardiac and non-cardiac sequelae in multisystem inflammatory syndrome in children associated with COVID-19 (MIS-C), which are currently poorly understood.This multicenter observational cohort study will enroll at least 600 patients <21 years old who meet the Centers for Disease Control and Prevention case definition of MIS-C across multiple North American centers over 2 years. The study will collect detailed hospital and follow-up data for up to 5 years, and optional genetic testing. Cardiac imaging at specific time points includes standardized echocardiographic assessment (all participants) and cardiac magnetic resonance imaging (CMR) in those with left ventricular ejection fraction (LVEF) <45% during the acute illness. The primary outcomes are the worst LVEF and the highest coronary artery z-score of the left anterior descending or right coronary artery. Other outcomes include occurrence and course of non-cardiac organ dysfunction, inflammation, and major medical events. Independent adjudication of cases will classify participants as definite, possible, or not MIS-C. Analysis of the outcomes will include descriptive statistics and regression analysis with stratification by definite or possible MIS-C. The MUSIC study will provide phenotypic data to support basic and translational research studies.The MUSIC study, with the largest cohort of MIS-C patients and the longest follow-up period to date, will make an important contribution to our understanding of the acute cardiac and non-cardiac manifestations of MIS-C and the long-term effects of this public health emergency.