Portal de Periódicos da CAPES

Artigo Acesso aberto Produção Nacional Revisado por pares

BIBTEX RIS

Clinical Features of COVID-19 on Patients With Neuromyelitis Optica Spectrum Disorders

2021; Wolters Kluwer; Volume: 8; Issue: 6 Linguagem: Inglês

10.1212/nxi.0000000000001060

2332-7812

Samira Luísa Apóstolos‐Pereira, Lis Campos Ferreira, Mateus Boaventura de Oliveira, Nise Alessandra de Carvalho Sousa, Gabriela J. Martins, José Artur Costa d’Almeida, Milena Sales Pitombeira, Lucas Silvestre Mendes, Thiago Gonçalves Fukuda, Hideraldo Luíz Souza Cabeça, Luciano Chaves Rocha, Bianca Etelvina Santos de Oliveira, Carla Stella, Enedina Maria Lobato de Oliveira, Leizian de Souza Amorim, Andréa Ferrari de Castro, Antônio Pereira Gomes Neto, Guilherme Diogo Silva, Lucas Bueno, Maria de Morais Machado, Rafael Dias-Carneiro, Ronaldo Maciel Dias, Alvaro Porto Moreira, Ana Cláudia Piccolo, Anderson Kuntz Grzesiuk, André Muniz, Caio César Diniz Disserol, Claudia Ferreira Vasconcelos, Damacio Ramón Kaimen-Maciel, Denise Sisterolli Diniz, Elizabeth Regina Comini-Frota, Maria Sheila Guimarães Rocha, Gutemberg Augusto Cruz dos Santos, Yára Dadalti Fragoso, Guilherme Sciascia do Olival, Heloísa Helena Ruocco, Heloise Helena Siqueira, Henry Koity Sato, José Alexandre Figueiredo, Leandro Cortoni Calia, Mário Emílio Teixeira Dourado Júnior, L Scolari, Herval Ribeiro Soares Neto, Luiz Domingos Mendes Melges, Marcus Vinícius Magno Gonçalves, Maria Lúcia Vellutini Pimentel, Marlise de Castro Ribeiro, Omar Gurrola Arambula, Paulo Diniz da Gama, Renata Leite Menon, Rodrigo Barbosa Thomaz, Rogério de Rizo Morales, Silvana Sobreira, Suzana Nunes Machado, Taysa Gonsalves Jubé Ribeiro, Valéria Coelho Santa Rita Pereira, Vanessa Maia Costa, Adaucto Wanderley da Nóbrega, Soniza Vieira Alves‐Leon, Mayara Caroline Perin, Eduardo Antônio Donadi, Tarso Adoni, Sidney Gomes, Maria Brito Ferreira, Dagoberto Callegaro, María Fernanda Mendes, Doralina Guimarães Brum, Felipe von Glehn,

COVID-19 and healthcare impacts

Background and Objectives To describe the clinical features and disease outcomes of coronavirus disease 2019 (COVID-19) in patients with neuromyelitis optica spectrum disorder (NMOSD). Methods The Neuroimmunology Brazilian Study Group has set up the report of severe acute respiratory syndrome (SARS-CoV2) cases in patients with NMOSD (pwNMOSD) using a designed web-based case report form. All neuroimmunology outpatient centers and individual neurologists were invited to register their patients across the country. Data collected between March 19 and July 25, 2020, were uploaded at the REDONE.br platform. Inclusion criteria were as follows: (1) NMOSD diagnosis according to the 2015 International Panel Criteria and (2) confirmed SARS-CoV2 infection (reverse transcription-polymerase chain reaction or serology) or clinical suspicion of COVID-19, diagnosed according to Center for Disease Control / Council of State and Territorial Epidemiologists (CDC/CSTE) case definition. Demographic and NMOSD-related clinical data, comorbidities, disease-modifying therapy (DMT), COVID-19 clinical features, and severity were described. Results Among the 2,061 pwNMOSD followed up by Brazilian neurologists involved on the registry of COVID-19 in pwNMOSD at the REDONE.br platform, 34 patients (29 women) aged 37 years (range 8–77), with disease onset at 31 years (range 4–69) and disease duration of 6 years (range 0.2–20.5), developed COVID-19 (18 confirmed and 16 probable cases). Most patients exhibited mild disease, being treated at home (77%); 4 patients required admission at intensive care units (severe cases); and 1 patient died. Five of 34 (15%) presented neurologic manifestations (relapse or pseudoexacerbation) during or after SARS-CoV2 infection. Discussion Most NMOSD patients with COVID-19 presented mild disease forms. However, pwNMOSD had much higher odds of hospitalization and intensive care unit admission comparing with the general Brazilian population. The frequency of death was not clearly different. NMOSD disability, DMT type, and comorbidities were not associated with COVID-19 outcome. SARS-CoV2 infection was demonstrated as a risk factor for NMOSD relapses. Collaborative studies using shared NMOSD data are needed to suitably define factors related to COVID-19 severity and neurologic manifestations.