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Manifestations of hyperparathyroidism in the jaws: Concepts, mechanisms, and clinical aspects

2021; Elsevier BV; Volume: 133; Issue: 5 Linguagem: Inglês

10.1016/j.oooo.2021.08.020

2212-4411

Letícia Martins Guimarães, Alline Teixeira Valeriano, Hélder Antônio Rebelo Pontes, Ricardo Santiago Gomez, Carolina Cavaliéri Gomes,

Bone and Dental Protein Studies

Hyperparathyroidism is one of the most common endocrine disorders worldwide. In countries where routine biochemical screening is not common, symptomatic hyperparathyroidism predominates. Its manifestations include skeletal alterations, calcification of soft tissues, kidney stones, and functional alterations in other systems. Notably, jaw alterations can be the first clinical sign of hyperparathyroidism, including brown tumor, renal osteodystrophy, osteitis fibrosa, and leontiasis ossea, and knowing such conditions is of core importance for the multidisciplinary diagnosis and management of hyperparathyroidism. We aimed to perform a concise review, systematizing the concepts and mechanisms underlying hyperparathyroidism and associated gnathic alterations. In addition, a detailed description of the clinical aspects of the jaw manifestations is presented.