Nanotechnology-based drug delivery for central nervous system disorders
2021; Elsevier BV; Volume: 143; Linguagem: Inglês
10.1016/j.biopha.2021.112117
ISSN1950-6007
AutoresThuy Trang Nguyen, Thi Thuy Dung Nguyen, Tuong Kha Vo, Tran Nguyen Minh An, Minh Kim Nguyen, Vo Van Toi, Vo Van Giau,
Tópico(s)Graphene and Nanomaterials Applications
ResumoDrug delivery to central nervous system (CNS) diseases is very challenging since the presence of the innate blood-brain barrier (BBB) and the blood-cerebrospinal fluid barrier that impede drug delivery. Among new strategies to overcome these limitations and successfully deliver drugs to the CNS, nanotechnology-based drug delivery platform, offers potential therapeutic approach for the treatment of some common neurological disorders like Alzheimer's disease, frontotemporal dementia, amyotrophic lateral sclerosis, Parkinson's disease, Huntington's disease. This review aimed to highlight advances in research on the development of nano-based therapeutics for their implications in therapy of CNS disorders. The challenges during clinical translation of nanomedicine from bench to bed side is also discussed.
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