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Global Respiratory Syncytial Virus–Related Infant Community Deaths

2021; Oxford University Press; Volume: 73; Issue: Supplement_3 Linguagem: Inglês

10.1093/cid/ciab528

1537-6591

Natalie I Mazur, Yvette N. Löwensteyn, Joukje E. Willemsen, Christopher Gill, Leah S. Forman, Lawrence Mwananyanda, Dianna M. Blau, Robert F. Breiman, Shabir A. Madhi, Sana Mahtab, Emily S. Gurley, Shams El Arifeen, Nega Assefa, J. Anthony G. Scott, Dickens Onyango, Beth A. Tippet Barr, Karen L. Kotloff, Samba O. Sow, Inácio Mandomando, Ikechukwu U. Ogbuanu, Amara Jambai, Quique Bassat, Somsak Thamthitiwat, Ángela Gentile, María Florencia Lución, Márcia Rosane Pires, Fernanda de Paris, Aubree Gordon, Félix Sánchez, Marilla Lucero, Socorro Lupisan, Bradford D. Gessner, Haoua Tall, Natasha Halasa, Najwa Khuri‐Bulos, D. James Nokes, Patrick K. Munywoki, Grieven P. Otieno, Katherine L. O’Brien, Katherine L Oshitani, María Tereza da Costa Oliveira, Carla Cecília de Freitas Lázaro Emediato, Asad Ali, Uzma Bashir Aamir, Daniel E. Noyola, Cheryl Cohen, Jocelyn Moyes, H. I. G. GIAMBERARDINO, Jane Melissa Webler, Patrícia Gomes de Matos Bezerra, Maria do Carmo Menezes Bezerra Duarte, Helen Y. Chu, Rashmi Ranjan Das, Martin W. Weber, Nusrat Homaira, Adam Jaffé, Katharine Sturm‐Ramirez, Wei Su, Chiang Chun Yuan, Sandra S. Chaves, Gideon O. Emukule, Sérgio de Andrade Nishioka, Felipe Cotrim de Carvalho, Şule Gökçe, Sônia Mara Raboni, Michael Hawkes, Mélina Messaoudi, Juliet E. Bryant, Ghassan Dbaibo, Rima Hanna‐Wakim, Jayaweera Arachchige Asela Sampath Jayaweera, K. A. Stolyarov, Piyarat Suntarattiwong, Tufária Mussá, Alfredo Bruno, Doménica de Mora, Nasamon Wanlapakorn, Zheng Xie, Junhong Ai, Jenny Ojeda, L. Lucas Zamora, Evangeline Obodai, John Kofi Odoom, Maha Talaat Ismail, Andrea G. Buchwald, Cristina O’Callaghan‐Gordo, Jaime Fernández‐Sarmiento, Evelyn Obando-Belalcazar, Tapan N. Dhole, Sheetal Verma, Aykut Eşki, G Ozturk Kartal, Mohammed Al Amad, Abdul Wahed Al Serouri, Yoke FunChan, Jamal I-Ching Sam, Daniel Jarovsky, Daniella Gregória Bomfim Prado da Silva, Jose Gareca Pérales, Teck‐Hock Toh, Jeffrey Lee Soon Yit, Tanıl Kendirli, Emrah Gün, Tani Sagna, Serge Diagbouga, Fahmida Chowdhury, Md. Ariful Islam, Marietjie Venter, Adele Visser, Minh-Hong Pham, Pablo Vásquez‐Hoyos, Sebastián González‐Dambrauskas, Franco Díaz, Todd Karsies, Eliana Zemanate, Ledys Izquierdo, Rubén Lasso Palomino, Rosalba Pardo-Carrero, Reginna Grigolli-Cesar, Soledad Menta, Nicolás Monteverde, Muhterem Duyu, Senjuti Saha, Samir K. Saha, Matthew Kelly, Marcela Echavarría, Tuan Anh Tran, Aida Borgi, Ahmed Ayari, Mauricio T. Caballero, Fernando P. Polack, Saad B. Omer, Abdul Momin Kazi, Eric A. F. Simões, Ashish Satav, Louis Bont,

Pneumonia and Respiratory Infections

Respiratory syncytial virus (RSV) is a leading cause of pediatric death, with >99% of mortality occurring in low- and lower middle-income countries. At least half of RSV-related deaths are estimated to occur in the community, but clinical characteristics of this group of children remain poorly characterized.The RSV Global Online Mortality Database (RSV GOLD), a global registry of under-5 children who have died with RSV-related illness, describes clinical characteristics of children dying of RSV through global data sharing. RSV GOLD acts as a collaborative platform for global deaths, including community mortality studies described in this supplement. We aimed to compare the age distribution of infant deaths <6 months occurring in the community with in-hospital.We studied 829 RSV-related deaths <1 year of age from 38 developing countries, including 166 community deaths from 12 countries. There were 629 deaths that occurred <6 months, of which 156 (25%) occurred in the community. Among infants who died before 6 months of age, median age at death in the community (1.5 months; IQR: 0.8-3.3) was lower than in-hospital (2.4 months; IQR: 1.5-4.0; P < .0001). The proportion of neonatal deaths was higher in the community (29%, 46/156) than in-hospital (12%, 57/473, P < 0.0001).We observed that children in the community die at a younger age. We expect that maternal vaccination or immunoprophylaxis against RSV will have a larger impact on RSV-related mortality in the community than in-hospital. This case series of RSV-related community deaths, made possible through global data sharing, allowed us to assess the potential impact of future RSV vaccines.