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The International Database of Central Arterial Properties for Risk Stratification: Research Objectives and Baseline Characteristics of Participants

2021; Oxford University Press; Volume: 35; Issue: 1 Linguagem: Inglês

10.1093/ajh/hpab139

1941-7225

Lucas S. Aparicio, Qi‐Fang Huang, Jesús D. Melgarejo, Dongmei Wei, Lutgarde Thijs, Fang‐Fei Wei, Natasza Gilis‐Malinowska, Chang‐Sheng Sheng, José Boggia, Teemu Niiranen, Augustine N. Odili, Katarzyna Stolarz‐Skrzypek, Jessica Barochiner, Daniel Ackermann, Kalina Kawecka−Jaszcz, Valérie Tikhonoff, Zhen‐Yu Zhang, Edoardo Casiglia, Krzysztof Narkiewicz, Jan Filipovský, Aletta E. Schutte, Wen‐Yi Yang, Antti Jula, Angela J. Woodiwiss, Murielle Bochud, Gavin R. Norton, Ji‐Guang Wang, Yan Li, Jan A. Staessen, Lucas S. Aparicio, Jessica Barochiner, Dongmei Wei, Jesús D. Melgarejo, Lutgarde Thijs, Jan A. Staessen, FF Wei, W.-Y. Yang, ZY Zhang, De‐Wei An, Y B Cheng, Qinghua Guo, Junxuan Huang, Qi‐Fang Huang, Y Li, Chang‐Sheng Sheng, J G Wang, Jan Filipovský, Jitka Seidlerová, E. Juhanoja, Antti Jula, Annika Lindroos, Teemu Niiranen, S. Sivén, Edoardo Casiglia, A Pizzioli, Valérie Tikhonoff, Babangida S. Chori, Benjamin Danladi, A N Odili, Henry Oshaju, W. Kucharska, Katarzyna Kunicka, Natasza Gilis‐Malinowska, Krzysztof Narkiewicz, Wojciech Sakiewicz, Ewa Świerblewska, Kalina Kawecka−Jaszcz, Katarzyna Stolarz‐Skrzypek, Marek Rajzer, Catharina M. C. Mels, Ruan Kruger, Gontse Mokwatsi, Aletta E. Schutte, Gavin R. Norton, Angela J. Woodiwiss, Daniel Ackermann, Murielle Bochud, Georg Ehret, Ramón Álvarez-Vaz, C. Americo, Cecilia Baccino, Luciana Borgarello, Lucía Florio, Paula Moliterno, Agustín Noboa, Óscar Noboa, Alicia Olascoaga, Paula Parnizari, M Pécora,

Blood Pressure and Hypertension Studies

Abstract OBJECTIVE To address to what extent central hemodynamic measurements, improve risk stratification, and determine outcome-based diagnostic thresholds, we constructed the International Database of Central Arterial Properties for Risk Stratification (IDCARS), allowing a participant-level meta-analysis. The purpose of this article was to describe the characteristics of IDCARS participants and to highlight research perspectives. METHODS Longitudinal or cross-sectional cohort studies with central blood pressure measured with the SphygmoCor devices and software were included. RESULTS The database included 10,930 subjects (54.8% women; median age 46.0 years) from 13 studies in Europe, Africa, Asia, and South America. The prevalence of office hypertension was 4,446 (40.1%), of which 2,713 (61.0%) were treated, and of diabetes mellitus was 629 (5.8%). The peripheral and central systolic/diastolic blood pressure averaged 129.5/78.7 mm Hg and 118.2/79.7 mm Hg, respectively. Mean aortic pulse wave velocity was 7.3 m per seconds. Among 6,871 participants enrolled in 9 longitudinal studies, the median follow-up was 4.2 years (5th–95th percentile interval, 1.3–12.2 years). During 38,957 person-years of follow-up, 339 participants experienced a composite cardiovascular event and 212 died, 67 of cardiovascular disease. CONCLUSIONS IDCARS will provide a unique opportunity to investigate hypotheses on central hemodynamic measurements that could not reliably be studied in individual studies. The results of these analyses might inform guidelines and be of help to clinicians involved in the management of patients with suspected or established hypertension.