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Neuroprotective potential of extracts from leaves of ora-pro-nobis (Pereskia aculeata) recovered by clean compressed fluids

2021; Elsevier BV; Volume: 179; Linguagem: Inglês

10.1016/j.supflu.2021.105390

1872-8162

Talyta Mayara Silva Torres, Gerardo Álvarez‐Rivera, Simone Mazzutti, José David Sánchez-Martínez, Alejandro Cifuentes, Elena Ibáñez, Sandra Regina Salvador Ferreira,

Essential Oils and Antimicrobial Activity

Ora-pro-nobis ( Pereskia aculeata ), an emerging unconventional food plant belonging to the Cactaceae family, is known as a source of protein with high nutritional value, traditionally used in folk medicine. In this study, different compressed fluid technologies were used to obtain antioxidant rich extracts from P. aculeata leaves. The recovered extracts from ora-pro-nobis leaves showed, in general, high antioxidant potential in DPPH and FRAP in vitro assays. Complementary, supercritical fluid extracts presented acetylcholinesterase inhibition and anti-inflammatory activity. Overall, 11 compounds were identified from the non-polar extracts belonging to terpenoids and phenolic compounds. Metabolites like 2,4-Ditert-butylphenol, β-sitosterol, campesterol, phytol, Vitamin E were already identified in other Pereskia sp. extracts, but compounds like fucosterol and lupeol were also tentatively identified in the present study. Terpenes and phenolic compounds are known for its biological activities, which shows the potentiality of the P. aculeata leaves extracts recovery by compressed fluids technologies. • Ethanol, water and CO 2 , at high pressures, are valuable solvents. • High pressure methods were efficient solvents to recover antioxidant- rich extracts. • SFE samples have anti-inflammatory activity. • SFE samples presented moderate anticholinergic activity. • SFE extracts present acetylcholinesterase inhibition and anti-inflammatory effect.