Portal de Periódicos da CAPES

Deaths Attributed to Respiratory Syncytial Virus in Young Children in High–Mortality Rate Settings: Report from Child Health and Mortality Prevention Surveillance (CHAMPS)

2021; Oxford University Press; Volume: 73; Issue: Supplement_3 Linguagem: Inglês

10.1093/cid/ciab509

1537-6591

Dianna M. Blau, Vicky L. Baillie, Toyah Els, Sana Mahtab, Portia Mutevedzi, Adama Mamby Keita, Karen L. Kotloff, Ashka Mehta, Samba O. Sow, Milagritos D. Tapia, Beth A. Tippett Barr, Benard O Oluoch, Clayton Onyango, Gunturu Revathi, Jennifer R. Verani, Mahlet Abayneh, Nega Assefa, Lola Madrid, Joseph Oundo, J. Anthony G. Scott, Quique Bassat, Inácio Mandomando, António Sitoe, Marta Valente, Rosauro Varo, Ima-Abasi Bassey, Carrie Jo Cain, Amara Jambai, Ikechukwu U. Ogbuanu, Julius Ojulong, Muntasir Alam, Shams El Arifeen, Emily S. Gurley, Afruna Rahman, Mustafizur Rahman, Jessica L. Waller, Betsy Dewey, Robert F. Breiman, Cynthia G. Whitney, Shabir A. Madhi, Yasmin Adam, Janet Agaya, Sara Ajanovic, Addisu Alemu, Solomon Ali, George Aol, Henry Badji, Sanwarul Bari, Justina Bramugy, James Bunn, Richard Chawana, Atique Iqbal Chowdhury, Karen D. Fairchild, Surafel Fentaw, Meerjady Sabrina Flora, Dickson Gethi, Nelesh P. Govender, Carol L. Greene, Tadesse Gure, Martin Hale, Juan Carlos Hurtado, Kitiezo Aggrey Igunza, Farzana Islam, Jennifer Johnson, Tatiana Keita, Sammy Khagayi, Iqbal Ansary Khan, Rima Koka, Diakaridia Kone, Nana Kourouma, Magdalene Kuria, Sandra Lako, Sanjay G. Lala, Hennie Lombaard, Ronita Luke, Thomas Misore, Paul K Mitei, Alexander M. Ibrahim, Andrew Moultrie, Florence Murila, Nellie Myburgh, Peter Nyamthimba, Richard Oliech, Richard Omore, Uma U. Onwuchekwa, Stian Magnus Staurung Orlien, Louis Othieno, Peter Otieno, Kephas Otieno, Gregory Ouma, Benard Owuor, Shahana Parveen, Karen L. Petersen, Mahbubur Rahman, Natalia Rakislova, Emily Rogena, Doh Sanogo, Tahmina Shirin, Diakaridia Sidibé, Seydou Sissoko, Fatima Solomon, Gillian Sorour, James Sylvester Squire, Peter J. Swart, Fikremelekot Temesgen, Sharon M. Tennant, Bukiwe Thwala, Cheick Bougadari Traoré, Sithembiso Velaphi, Pio Vitorino, Jeannette Wadula, Melisachew Mulatu Yeshi,

Viral gastroenteritis research and epidemiology

Abstract Background Lower respiratory tract infections are a leading cause of death in young children, but few studies have collected the specimens needed to define the role of specific causes. The Child Health and Mortality Prevention Surveillance (CHAMPS) platform aims to investigate causes of death in children aged <5 years in high–mortality rate settings, using postmortem minimally invasive tissue sampling and other advanced diagnostic techniques. We examined findings for deaths identified in CHAMPS sites in 7 countries in sub-Saharan Africa and south Asia to evaluate the role of respiratory syncytial virus (RSV). Methods We included deaths that occurred between December 2016 and December 2019. Panels determined causes of deaths by reviewing all available data including pathological results from minimally invasive tissue sampling, polymerase chain reaction screening for multiple infectious pathogens in lung tissue, nasopharyngeal swab, blood, and cerebrospinal fluid samples, clinical information from medical records, and verbal autopsies. Results We evaluated 1213 deaths, including 695 in neonates (aged <28 days), 283 in infants (28 days to <12 months), and 235 in children (12–59 months). RSV was detected in postmortem specimens in 67 of 1213 deaths (5.5%); in 24 deaths (2.0% of total), RSV was determined to be a cause of death, and it contributed to 5 other deaths. Younger infants (28 days to <6 months of age) accounted for half of all deaths attributed to RSV; 6.5% of all deaths in younger infants were attributed to RSV. RSV was the underlying and only cause in 4 deaths; the remainder (n = 20) had a median of 2 (range, 1–5) other conditions in the causal chain. Birth defects (n = 8) and infections with other pathogens (n = 17) were common comorbid conditions. Conclusions RSV is an important cause of child deaths, particularly in young infants. These findings add to the substantial body of literature calling for better treatment and prevention options for RSV in high–mortality rate settings.