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Treatment with Gaoziban Tablet Ameliorates Depression by Promoting GSK-3β Phosphorylation to Enhance the Wnt/β-catenin Activation in the Hippocampus of Rats

2021; Volume: 000; Issue: 000 Linguagem: Inglês

10.14218/jerp.2021.00016

2572-5505

Xin-Shuang Zou, Hai-Long Yin, Lei Shi, Haiping Li, Mengheng Wang, Wanci Song, Yang Luo, Wei‐Liang Chen, Wu H, Yanfang Yang, Jun-Feng Zan, Liu Yan-wen, Hanxiong Dan, Qiang Yin, Pengtao You,

Stress Responses and Cortisol

Background and objectivesDepression is a severe and recurrent mental disease and contributes to the global disease burden. However, there are limited effective treatments for depression. This study evaluated the effect of a compound Gaoziban tablet (CGZBT) on depression and explored its potential mechanisms that underlie its action in rats.