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Prevention of Cardiac Surgery-Associated Acute Kidney Injury By Risk Stratification Using (Timp-2)*(Igfbp7)

2021; Future Medicine; Volume: 15; Issue: 14 Linguagem: Inglês

10.2217/bmm-2020-0656

1752-0371

Charlène Couturier, Nicolas Maillard, Christophe Mariat, Jérôme Morel, Jean-Charles Palao, Jean-Baptiste Bouchet, Guillaume Claisse,

Cardiac, Anesthesia and Surgical Outcomes

Aim: The purpose of this study was to assess urinary (TIMP-2)*(IGFBP7) for prevention of acute kidney injury (AKI) in patients undergoing elective cardiac surgery. Materials & methods: Two retrospective cohorts were analyzed before and after the implementation of urinary (TIMP-2)*(IGFBP7). The control cohort had a standard supportive care. For the (TIMP-2)*(IGFBP7) cohort, patients with the (TIMP-2)*(IGFBP7) >0.3 received renal supportive measures. Results: A total of 382 patients were included, 197 in the control cohort and 185 in intervention cohort. The incidence of AKI was significantly reduced in the (TIMP-2)*(IGFBP7) cohort (20.5 vs 29.9%, p < 0.05). In multivariate analysis, patients of the (TIMP-2)*(IGFBP7) cohort had a lower risk of developing AKI (p = 0.029). Conclusion: In conclusion, renal supporting care based on AKI risk stratification using urinary (TIMP-2)*(IGFBP7) may reduce AKI incidence.